Teniposide cas no:29767-20-2
Synonyms: Epipodophyllotoxin,4'-demethyl-, 9-(4,6-O-2-thenylidene-b-D-glucopyranoside) (8CI);Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-b-D-glucopyranosyl]oxy]-, [5R-[5a,5ab,8aa,9b(R*)]]-;EPT;NSC 122819;S 122819;Tenoposide;VM 26;Vehem;Vehem-Sandoz;Vumon;
NameTeniposide
CAS29767-20-2
SynonymsEpipodophyllotoxin,4'-demethyl-, 9-(4,6-O-2-thenylidene-b-D-glucopyranoside) (8CI);Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-b-D-glucopyranosyl]oxy]-, [5R-[5a,5ab,8aa,9b(R*)]]-;EPT;NSC 122819;S 122819;Tenoposide;VM 26;Vehem;Vehem-Sandoz;Vumon;
EINECS(EC#)249-831-2
Molecular FormulaC32H32O13S
Molecular Weight656.66
Appearancewhite or off-white crystalline powder
refractive index1.697
Hazard Xi
Risk R36/37/38
Safety
Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion and intravenous route: anorexia, nausea or vomiting, leukopenia, agranulocytosis and aplastic anemia of the blood, bone marrow changes, and hair changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx.
Hazard Codes of ETP (CAS NO.29767-20-2): 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| human |
TDLo |
intravenous |
26mg/kg/10D-I (26mg/kg) |
BLOOD: AGRANULOCYTOSIS
BLOOD: APLASTIC ANEMIA
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Cancer Vol. 34, Pg. 985, 1974. |
| human |
TDLo |
intravenous |
132mg/kg/7W-I (132mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: LEUKOPENIA |
Cancer Treatment Reports. Vol. 63, Pg. 7, 1979. |
| human |
TDLo |
oral |
9579mg/kg (9579mg/kg) |
BEHAVIORAL: ANOREXIA (HUMAN
GASTROINTESTINAL: NAUSEA OR VOMITING
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
European Journal of Cancer. Vol. 14, Pg. 1395, 1978. |
| mouse |
LD50 |
intraperitoneal |
29570ug/kg (29.57mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
subcutaneous |
31560ug/kg (31.56mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| rat |
LD17 |
intraperitoneal |
50mg/kg (50mg/kg) |
|
Cancer Treatment Reports. Vol. 60, Pg. 1127, 1976. |
| rat |
LDLo |
intravenous |
15mg/kg (15mg/kg) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: LEUKOPENIA |
Proceedings of the European Society of Toxicology. Vol. 17, Pg. 171, 1976. |
