child |
TDLo |
oral |
19mg/kg/4W-I (19mg/kg) |
PERIPHERAL NERVE AND SENSATION: FASCICULATIONS |
Pediatrics. Vol. 73, Pg. 841, 1984. |
child |
TDLo |
oral |
25926ug/kg (25.926mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 320, 1993. |
child |
TDLo |
oral |
55mg/kg (55mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA |
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 323, 2000. |
child |
TDLo |
oral |
65mg/kg (65mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Journal of Pediatrics. Vol. 121, Pg. 295, 1992. |
child |
TDLo |
oral |
420mg/kg/3W-I (420mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: GENERAL ANESTHETIC |
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 109, 1998. |
child |
TDLo |
oral |
1050mg/kg/6W- (1050mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
American Journal of Psychiatry. Vol. 143, Pg. 1176, 1985. |
dog |
LD50 |
oral |
5620mg/kg (5620mg/kg) |
? |
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972. |
guinea pig |
LD50 |
oral |
920mg/kg (920mg/kg) |
? |
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972. |
human |
TDLo |
oral |
43mg/kg (43mg/kg) |
BEHAVIORAL: SLEEP
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING |
British Medical Journal. Vol. 1, Pg. 754, 1977. |
man |
LDLo |
oral |
54mg/kg/9D-I (54mg/kg) |
BEHAVIORAL: ATAXIA
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
BLOOD: AGRANULOCYTOSIS |
Canadian Medical Association Journal. Vol. 132, Pg. 1040, 1985. |
man |
TDLo |
oral |
94mg/kg/11D-I (94mg/kg) |
BLOOD: THROMBOCYTOPENIA |
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 305, 1990. |
man |
TDLo |
oral |
160mg/kg/3W-I (160mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Journal of Clinical Pyschopharmacology. Vol. 5, Pg. 185, 1985. |
man |
TDLo |
oral |
253mg/kg/6W-I (253mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 251, 1986. |
mouse |
LD50 |
intraperitoneal |
114mg/kg (114mg/kg) |
? |
Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990. |
mouse |
LD50 |
oral |
529mg/kg (529mg/kg) |
? |
Farmaco. Vol. 44, Pg. 595, 1989. |
mouse |
LD50 |
subcutaneous |
> 1gm/kg (1000mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980. |
rabbit |
LD50 |
oral |
2680mg/kg (2680mg/kg) |
? |
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972. |
rat |
LD50 |
intraperitoneal |
158mg/kg (158mg/kg) |
? |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 202, Pg. 106, 1973. |
rat |
LD50 |
oral |
1957mg/kg (1957mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Japanese Kokai Tokyo Koho Patents. Vol. #79-163823, |
rat |
LD50 |
subcutaneous |
> 1500mg/kg (1500mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980. |
women |
LDLo |
oral |
1920mg/kg/17W (1920mg/kg) |
BLOOD: APLASTIC ANEMIA |
American Journal of Psychiatry. Vol. 142, Pg. 974, 1985. |
women |
TDLo |
oral |
28mg/kg/4D-I (28mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING |
American Journal of Psychiatry. Vol. 143, Pg. 1328, 1986. |
women |
TDLo |
oral |
112mg/kg/2W-I (112mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: THROMBOCYTOPENIA |
American Journal of Psychiatry. Vol. 150, Pg. 1750, 1993. |
women |
TDLo |
oral |
144mg/kg/2W-I (144mg/kg) |
BLOOD: THROMBOCYTOPENIA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
Journal of Clinical Psychiatry. Vol. 53, Pg. 378, 1992. |
women |
TDLo |
oral |
560mg/kg/4W-I (560mg/kg) |
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
British Journal of Clinical Practice. Vol. 43, Pg. 302, 1989. |
women |
TDLo |
oral |
7604mg/kg/69W (7604mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE |
Japanese Heart Journal. Vol. 39, Pg. 469, 1998.
? |