Phosphoramidic acid,N-methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester cas no:299-86-5

NamePhosphoramidic acid,N-methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester
CAS299-86-5
SynonymsPhosphoramidicacid, methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester (9CI);Phosphoramidic acid, methyl-, 4-tert-butyl-2-chlorophenyl methyl ester(6CI,8CI); 4-tert-Butyl-2-chlorophenyl N-methyl O-methylphosphoramidate;4-tert-Butyl-2-chlorophenyl methyl N-methylphosphoramidate;4-tert-Butyl-2-chlorophenyl methyl methylphosphoramidate; Amidofos; Amidophos;Crufomat; Crufomate; Dowco 132; Montrel; NSC 253463; Ruelene; Ruelene drench
EINECS(EC#)206-083-1
Molecular FormulaC12H19 Cl N O3 P
Molecular Weight291.74

refractive index1.501

Hazard Xn,N
Risk 21/22-50/53
Safety

A poison by ingestion and inhalation. Moderately toxic via skin contact and possibly other routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of PO_x, NO_x, and Cl⁻.
 

Hazard Codes Xn,N
Risk Statements 21/22-50/53
R21/22: Cruformate (CAS NO.299-86-5) is harmful in contact with skin and if swallowed. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 36/37-60-61
R36/37:Irritating to eyes and respiratory system. 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
dog	LD50	oral	1gm/kg (1000mg/kg)		VM/SAC, Veterinary Medicine and Small Animal Clinician. Vol. 74, Pg. 1119, 1979.
guinea pig	LD50	oral	1gm/kg (1000mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Food and Cosmetics Toxicology. Vol. 6, Pg. 185, 1968.
guinea pig	LDLo	subcutaneous	50mg/kg (50mg/kg)		Stauffer Chemical Co., Product Safety Information Sheets.
mammal (species unspecified)	LD50	oral	251mg/kg (251mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Veterinariya. Veterinary Science. Vol. 54(12), Pg. 94, 1978.
rabbit	LD50	oral	400mg/kg (400mg/kg)		"Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 59, 1976.
rabbit	LD50	skin	2gm/kg (2000mg/kg)		Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 37, 1978.
rat	LCLo	inhalation	12mg/m3/4H (12mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 29, 1982.
rat	LD50	oral	460mg/kg (460mg/kg)		Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rat	LD50	unreported	770mg/kg (770mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 317, 1971.