5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1), (6R,7R)- cas no:30034-03-8
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, [6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodiumsalt, D- (8CI); Cefamandole sodium; Cefamandole sodium salt; Kefdole; Sodium7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;Sodium [6R-[6a,7b(R*)]]-7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium cefamandole
Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1), (6R,7R)-
CAS30034-03-8
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, [6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodiumsalt, D- (8CI); Cefamandole sodium; Cefamandole sodium salt; Kefdole; Sodium7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;Sodium [6R-[6a,7b(R*)]]-7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium cefamandole
EINECS(EC#)250-009-0
Molecular FormulaC18H18 N6 O5 S2 . Na
Molecular Weight484.52
AppearanceWhite solid
storage tempStore at RT.
Hazard Xn: Harmful;
Risk R36/37/38;R42/43
Safety
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
Hazard Codes:
Xn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.?
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XI0389000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intravenous |
4460mg/kg (4460mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
| mouse |
LD50 |
oral |
> 19900mg/kg (19900mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
| mouse |
LD50 |
subcutaneous |
10300mg/kg (10300mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
| rabbit |
LD |
intravenous |
> 2gm/kg (2000mg/kg) |
behavioral: food intake (animal) kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" kidney, ureter, and bladder: other changes in urine composition
|
Chemotherapy Vol. 27(Suppl, |
| rat |
LD50 |
intravenous |
4410mg/kg (4410mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
| rat |
LD50 |
oral |
> 16600mg/kg (16600mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
| rat |
LD50 |
subcutaneous |
12100mg/kg (12100mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
