Tretinoin cas no:302-79-4
Synonyms: 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; all-trans-Retinoic acid; Vitamin A acid; Retionoic Acid; Tretinoin (Retionoic Acid); Tretinion
NameTretinoin
CAS302-79-4
Synonyms3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; all-trans-Retinoic acid; Vitamin A acid; Retionoic Acid; Tretinoin (Retionoic Acid); Tretinion
EINECS(EC#)206-129-0
Molecular FormulaC20H28O2
Molecular Weight300.44
AppearanceYellow-orange powder
Hazard Xn:Harmful
Risk R22;R38;R63
Safety
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Human mutation data reported. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of? Tretinoin (CAS NO.302-79-4):?
T,
Xn
Risk Statements: 22-63-38-20/21/22?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R22:Harmful if swallowed.?
R38:Irritating to skin.?
R63:Possible risk of harm to the unborn child.
Safety Statements: 53-26-36/37/39-45-36/37?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S53:Avoid exposure - obtain special instructions before use.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
208mg/kg (208mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 886, 1995. |
| mouse |
LD50 |
intravenous |
92mg/kg (92mg/kg) |
? |
United States Patent Document. Vol. #3878202, |
| mouse |
LD50 |
oral |
1100mg/kg (1100mg/kg) |
? |
American Journal of Clinical Nutrition. Vol. 52, Pg. 183, 1990. |
| mouse |
LD50 |
subcutaneous |
253mg/kg (253mg/kg) |
BEHAVIORAL: SLEEP
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. |
| rat |
LD50 |
intraperitoneal |
96mg/kg (96mg/kg) |
SPINAL CORD: OTHER DEGENERATIVE CHANGES
BEHAVIORAL: ATAXIA
BLOOD: NORMOCYTIC ANEMIA |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. |
| rat |
LD50 |
intravenous |
75mg/kg (75mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 886, 1995. |
| rat |
LD50 |
oral |
2gm/kg (2000mg/kg) |
? |
American Journal of Clinical Nutrition. Vol. 52, Pg. 183, 1990. |
| rat |
LD50 |
subcutaneous |
53mg/kg (53mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3194, 1973. |
