2-Butenoic acid,2-methyl-,(1S,7aR)-7-[[(2R)-2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ylester, (2Z)- cas no:303-34-4

Name2-Butenoic acid,2-methyl-,(1S,7aR)-7-[[(2R)-2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ylester, (2Z)-
CAS303-34-4
Synonyms2-Butenoicacid,2-methyl-,7-[[2,3-dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ylester, [1S-[1a(Z),7[S*(R*)],7aa]]-; Lasiocarpine (6CI,7CI,8CI);(-)-Lasiocarpine;7-Angelyleuropine;Europine 7-angelate;NSC 30625
Molecular FormulaC21H33 N O7
Molecular Weight411.55

Appearancecolourless to beige crystalline solid
refractive index1.544

Safety

Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and parenteral routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also ESTERS.
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

1.		sln-dmg-orl 750 ppm		ENMUDM    Environmental Mutagenesis. 7 (1985),349.
2.		trn-dmg-orl 750 ppm		ENMUDM    Environmental Mutagenesis. 7 (1985),349.
3.		orl-rat TDLo:255 mg/kg/2Y-C:CAR		NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-39 ,1978.
4.		ipr-rat TDLo:470 mg/kg/56W-I:CAR		CNREA8    Cancer Research. 32 (1972),908.
5.		orl-rat LD50:110 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 17 (1970),290.
6.		ipr-rat LD50:78 mg/kg		CNREA8    Cancer Research. 32 (1972),908.
7.		ivn-rat LD50:88 mg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.
8.		par-rat LD50:80 mg/kg		NATUAS    Nature. 223 (1969),1269.
9.		ivn-mus LDLo:85 mg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.
10.		ivn-mky LDLo:20 mg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179.