303-49-1|5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-Products Supply

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl- cas no:303-49-1

Synonyms: 5H-Dibenz[b,f]azepine,3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro- (6CI,7CI,8CI);3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;Chlorimipramine;G 34586;NSC 169865;

Identification

Name5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-
CAS303-49-1
Synonyms5H-Dibenz[b,f]azepine,3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro- (6CI,7CI,8CI);3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;Chlorimipramine;G 34586;NSC 169865;
EINECS(EC#)206-144-2
Molecular FormulaC₁₉H₂₃ClN₂
Molecular Weight314.85

Chemical Properties

Appearancewhite to off-white powder
refractive index1.581

Safety Data

Hazard Xn: Harmful;
Risk R20/21/22
Safety

Hazard Codes : Xn
Risk Statements: 20/21/22
20/21/22 : 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine hydrochloride (303-49-1 ) is harmful by inhalation, in contact with skin and if swallowed .
Safety Statements : 36
36: Keep away from sources of ignition - No smoking
WGK Germany: 3
RTECS: HN9055000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	357ug/kg (0.357mg/kg)	gastrointestinal: nausea or vomiting	Journal of Clinical Pyschopharmacology. Vol. 2, Pg. 215, 1982.
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		Journal of Medicinal Chemistry. Vol. 21, Pg. 448, 1978.
mouse	LD50	intravenous	27mg/kg (27mg/kg)		Acta Pharmaceutica Suecica. Vol. 13, Pg. 485, 1976.
mouse	LD50	oral	380mg/kg (380mg/kg)	behavioral: wakefulness behavioral: changes in motor activity (specific assay)	German Offenlegungsschrift Patent Document. Vol. #2618152,
rat	LD50	intraperitoneal	149mg/kg (149mg/kg)		Toxicology. Vol. 24, Pg. 335, 1982.
rat	LD50	oral	613mg/kg (613mg/kg)		Toxicology. Vol. 24, Pg. 335, 1982.
women	TDLo	intravenous	3400ug/kg/47M (3.4mg/kg)	behavioral: convulsions or effect on seizure threshold cardiac: cardiomyopathy including infarction	British Medical Journal. Vol. 3, Pg. 698, 1972.
women	TDLo	oral	10mg/kg/5D-I (10mg/kg)	vascular: bp elevation not characterized in autonomic section	British Medical Journal. Vol. 1, Pg. 406, 1971.
women	TDLo	oral	30mg/kg (30mg/kg)	behavioral: coma gastrointestinal: changes in structure or function of endocrine pancreas gastrointestinal: decreased motility or constipation	Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 425, 1994

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5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl- cas no:303-49-1

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