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Home > products > Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride(1:2)

Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride(1:2) cas no:30484-77-6

Synonyms: Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-;Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]-,dihydrochloride (9CI);Piperazine, 1-[bis(p-fluorophenyl)methyl]-4-cinnamyl-,dihydrochloride, (E)- (8CI);(E)-1-[Bis(4-fluorophenyl)methyl]-4-cinnamylpiperazinedihydrochloride;Dinaplex;Flugeral;Flunagen;Flunarizine hydrochloride;Flunarl;Fluxarten;Gradient;Issium;Mondus;R14950;

Identification
NamePiperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride(1:2)
CAS30484-77-6
SynonymsPiperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-;Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]-,dihydrochloride (9CI);Piperazine, 1-[bis(p-fluorophenyl)methyl]-4-cinnamyl-,dihydrochloride, (E)- (8CI);(E)-1-[Bis(4-fluorophenyl)methyl]-4-cinnamylpiperazinedihydrochloride;Dinaplex;Flugeral;Flunagen;Flunarizine hydrochloride;Flunarl;Fluxarten;Gradient;Issium;Mondus;R14950;
EINECS(EC#)250-216-6
Molecular FormulaC26H28Cl2F2N2
Molecular Weight404.494846
Chemical Properties
AppearanceWhite crystalline powder, odorless and tasteless
storage temp2-8°C
Safety Data

Hazard Xn:Harmful;
Risk R22
Safety

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl, NOx, and F.
Hazard Codes:
Xn: Harmful
Risk Statements about Flunarizine dihydrochloride (CAS No.:30484-77-6):
R22 Harmful if swallowed.


Toxicity
1.    

orl-rat LD50:503 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1408.
2.    

ipr-rat LD50:305 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.
3.    

scu-rat LD50:1793 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.
4.    

ivn-rat LD50:35 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.
5.    

orl-mus LD50:1203 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.
6.    

ipr-mus LD50:379 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.
7.    

ivn-mus LD50:27 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 36 (1985),825.

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