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Amezinium methylsulfate cas no:30578-37-1

Synonyms: Amezinium metilsulfate (JAN);Risumic (TN);Amezinium metilsulfate;6-methoxy-1-phenyl-pyridazin-4-amine; sulfonatooxymethane;Pyridazinium,4-amino-6-methoxy-1-phenyl-,methyl sulfate;Regulton;Lu 1631;MEZINIUM METHYL SULFATE;4-AMINO-6-METHOXY-1-PHENYLPYRID-AZINIUM-METHYLSULFAT (GERMAN);SUPRATONIN;4-AMINO-6-METHO-XY-1-PHENYLPYRIDAZINIUM METHYL SULFATE;AMEZINIUMMETILSULFAT (GERMAN);Risumic;

Identification
NameAmezinium methylsulfate
CAS30578-37-1
SynonymsAmezinium metilsulfate (JAN);Risumic (TN);Amezinium metilsulfate;6-methoxy-1-phenyl-pyridazin-4-amine; sulfonatooxymethane;Pyridazinium,4-amino-6-methoxy-1-phenyl-,methyl sulfate;Regulton;Lu 1631;MEZINIUM METHYL SULFATE;4-AMINO-6-METHOXY-1-PHENYLPYRID-AZINIUM-METHYLSULFAT (GERMAN);SUPRATONIN;4-AMINO-6-METHO-XY-1-PHENYLPYRIDAZINIUM METHYL SULFATE;AMEZINIUMMETILSULFAT (GERMAN);Risumic;
EINECS(EC#)250-248-0
Molecular FormulaC11H12N3O.CH3O4S
Molecular Weight313.33
Safety Data

Safety

Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 60mg/kg (60mg/kg)   Medicamentos de Actualidad. Vol. 18, Pg. 310, 1982.
dog LD50 oral 100mg/kg (100mg/kg)   Medicamentos de Actualidad. Vol. 18, Pg. 310, 1982.
mouse LD50 intravenous 24100ug/kg (24.1mg/kg)   Drugs in Japan Vol. -, Pg. 72, 1995.
mouse LD50 oral 1330mg/kg (1330mg/kg) behavioral: altered sleep time (including change in righting reflex) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1471, 1988.
mouse LD50 subcutaneous 282mg/kg (282mg/kg)   Drugs in Japan Vol. -, Pg. 72, 1995.
rabbit LD50 intravenous 25mg/kg (25mg/kg)   Medicamentos de Actualidad. Vol. 18, Pg. 310, 1982.
rabbit LD50 oral 800mg/kg (800mg/kg)   Medicamentos de Actualidad. Vol. 18, Pg. 310, 1982.
rat LD50 intravenous 24mg/kg (24mg/kg) behavioral: altered sleep time (including change in righting reflex) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1471, 1988.
rat LD50 oral 1330mg/kg (1330mg/kg)   Drugs in Japan Vol. -, Pg. 72, 1995.
rat LD50 subcutaneous 282mg/kg (282mg/kg)
behavioral: altered sleep time (including change in righting reflex) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1471, 1988.

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