Metrizamide cas no:31112-62-6
Synonyms: D-Glucose,2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy- (8CI);Amipaque;Telebrix 300;2-[3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzamido]-2-deoxy-D-glucose;D-Glucose, 2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-;3-Acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodo-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide;
NameMetrizamide
CAS31112-62-6
SynonymsD-Glucose,2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy- (8CI);Amipaque;Telebrix 300;2-[3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzamido]-2-deoxy-D-glucose;D-Glucose, 2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-;3-Acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodo-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide;
EINECS(EC#)250-475-5
Molecular FormulaC18H22I3N3O8
Molecular Weight789.09599
AppearanceWhite Powder
refractive index1.761
storage temp−20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety
Poison by subcutaneous, intracerebral, and parenteral routes. Moderately toxic by intraperitoneal and intravenous routes. Human systemic effects: meningeal changes to spinal cord. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of I− and NOx.
Safety Statements about Metrizamide (31112-62-6):
S22 Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
Attention:
1. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid ingestion and inhalation. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed.
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isp-man TDLo:143 mg/kg:CNS
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SMJOAV Southern Medical Journal. 77 (1984),88. |
| 2. |
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ipr-rat LD50:9300 mg/kg
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NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),842. |
| 3. |
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scu-rat LD50:17 mg/kg
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YKYUA6 Yakkyoku. Pharmacy. 32 (1981),865. |
| 4. |
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ivn-rat LD50:13,100 mg/kg
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NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),842. |
| 5. |
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ice-rat LD50:135 mg/kg
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RADLAX Radiology. 140 (1981),713. |
| 6. |
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ipr-mus LD50:9950 mg/kg
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USXXAM United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4001323 . |
| 7. |
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scu-mus LD50:7500 mg/kg
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NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),842. |
| 8. |
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ivn-mus LD50:1534 mg/kg
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INVRAV Investigative Radiology. 15 (Suppl)(1980),248. |
| 9. |
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ice-mus LD50:2910 mg/kg
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USXXAM United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4001323 . |
| 10. |
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