1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-,sodium salt (1:4) cas no:314-13-6
Synonyms: 1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-,tetrasodium salt (9CI); Azovan Blue (6CI); C.I. Direct Blue 53, tetrasodiumsalt (8CI); 4,4'-Bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3'-bitolyltetrasodium salt; C.I. 23860; C.I. Direct Blue 53; Diazol Pure Blue BF; DirectBlue 53; Evans Blue; Evan's Blue; T 1824
Name1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-,sodium salt (1:4)
CAS314-13-6
Synonyms1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-,tetrasodium salt (9CI); Azovan Blue (6CI); C.I. Direct Blue 53, tetrasodiumsalt (8CI); 4,4'-Bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3'-bitolyltetrasodium salt; C.I. 23860; C.I. Direct Blue 53; Diazol Pure Blue BF; DirectBlue 53; Evans Blue; Evan's Blue; T 1824
EINECS(EC#)206-242-5
Molecular FormulaC34H28 N6 O14 S4 . 4 Na
Molecular Weight960.84
Appearancedark brown
storage tempStore at RT.
Hazard F:Flammable
Risk R11;R45;R63
Safety
Poison by intraperitoneal route. Moderately toxic by intravenous route. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, Na2O, and NOx.
Hazard Codes:
T,
F
Risk Statements: 45-63-11-61-20/21/22?
R45:May cause cancer.?
R63:Possible risk of harm to the unborn child.?
R11:Highly flammable.?
R61:May cause harm to the unborn child.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-45-36/37-16-36/37/39?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37:Wear suitable protective clothing and gloves.?
S16:Keep away from sources of ignition.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
RTECS of Evans blue (CAS NO.314-13-6): QJ6440000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LDLo |
intravenous |
1mL/kg (1mL/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LIVER: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Archives of Surgery Vol. 48, Pg. 17, 1944. |
| dog |
LDLo |
intravenous |
3mL/kg (3mL/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
Archives of Surgery Vol. 48, Pg. 17, 1944. |
| mouse |
LD50 |
intraperitoneal |
340mg/kg (340mg/kg) |
? |
Biochemical and Biophysical Research Communications. Vol. 136, Pg. 64, 1986. |
| rabbit |
LDLo |
intravenous |
1mL/kg (1mL/kg) |
CARDIAC: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
Archives of Surgery Vol. 48, Pg. 17, 1944. |
| rat |
LDLo |
intravenous |
5mL/kg (5mL/kg) |
CARDIAC: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
Archives of Surgery Vol. 48, Pg. 17, 1944. |
