Verrucarin A cas no:3148-09-2

NameVerrucarin A
CAS3148-09-2
SynonymsSpiro[16,18-methano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2'-oxirane],verrucarin A deriv.; (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4,5,6,7,16,16a,19a,22-Octahydro-4-hydroxy-5,16a,21-trimethylspiro[16,18-methano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2'-oxirane]-3,9,14-trione;Muconomycin; Muconomycin A; NSC 126728; NSC 200736; Spiro[16,18-methano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2'-oxirane]-3,9,14-trione,4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy-5,16a,21-trimethyl-,(4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-
Molecular FormulaC27H34 O9
Molecular Weight502.61

refractive index1.584          
storage temp−20°C

Hazardclass6.1(a)

Hazard T+: Very toxic;
Risk 26/27/28
Safety

A poison by intravenous and intraperitoneal routes. Mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: T+
Risk Statements: 26/27/28 
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45 
S22: Do not breathe dust. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: WH1314900
HazardClass: 6.1(a)
PackingGroup: I

1.		skn-gpg 402 ng MLD		FAATDF    Fundamental and Applied Toxicology. 4 (2, Pt 2)(1984),S124.
2.		dni-mus:lym 1 nmol/L		PLMEAA    Planta Medica. 34 (1978),231.
3.		ivn-rat LD50:870 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 15 (1965),893.
4.		ipr-mus LD50:500 µg/kg		TXAPA9    Toxicology and Applied Pharmacology. 15 (1969),262.
5.		ivn-mus LD50:1500 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 15 (1965),893.
6.		ivn-rbt LD50:540 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 15 (1965),893.