315-30-0|4-Hydroxypyrazolo[3,4-d]pyrimidineProducts Supply

4-Hydroxypyrazolo[3,4-d]pyrimidine cas no:315-30-0

Synonyms: Allopurinol; Hydroxypyrazolodpyrimidine; pyrazolo(3,4-d)pyrimidin-1-ol; 4-Hydroxypyrazolo(3,4-d)-pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; ACO

Identification

Name4-Hydroxypyrazolo[3,4-d]pyrimidine
CAS315-30-0
SynonymsAllopurinol; Hydroxypyrazolodpyrimidine; pyrazolo(3,4-d)pyrimidin-1-ol; 4-Hydroxypyrazolo(3,4-d)-pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol; ACO
EINECS(EC#)206-250-9
Molecular FormulaC5H4N4O
Molecular Weight136.11

Chemical Properties

AppearanceWhite to Off-White Solid
refractive index1.816
storage tempStore in a tightly closed container. Store in a cool, dry area away from incompatible substances.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1

Safety Data

Hazard T:Toxic
Risk R25;R36/37/38;R43
Safety

Human poison by ingestion. Poison experimentally by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood leukopenia, dermatitis, jaundice, muscle weakness, thrombocytopenia. When heated to decomposition it emits toxic fumes of NO_x. An FDA proprietary drug used as a xanthine oxidase inhibitor.
Hazard Codes?of Allopurinol (CAS NO.315-30-0):? Toxic T, Irritant Xi, Harmful Xn
Risk Statements: 25-43-36/37/38-20/21/22
R25: Toxic if swallowed.?
R43: May cause sensitization by skin contact.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 28-36/37-45-36/37/39-26-24-36
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S24: Avoid contact with skin.?
S36: Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 2
RTECS: UR0785000
HazardClass: 6.1
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	21429ug/kg/5D (21.429mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" BLOOD: THROMBOCYTOPENIA	Annals of the Rheumatic Diseases. Vol. 40, Pg. 245, 1981.
man	TDLo	oral	120mg/kg/4W-I (120mg/kg)	BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Clinical and Experimental Dermatology. Vol. 19, Pg. 243, 1994.
mouse	LD50	intraperitoneal	214mg/kg (214mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: FLUID INTAKE BEHAVIORAL: ATAXIA	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 108, 1968.
mouse	LD50	oral	78mg/kg (78mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 7, Pg. 735, 1973.
mouse	LD50	subcutaneous	298mg/kg (298mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 715, 1981.
rabbit	LD	oral	> 100mg/kg (100mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 7, Pg. 735, 1973.
rat	LD	oral	> 500mg/kg (500mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 7, Pg. 735, 1973.
rat	LD50	intraperitoneal	900mg/kg (900mg/kg)	?	Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat	LD50	subcutaneous	2450mg/kg (2450mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 763, 1969.
women	LDLo	oral	88mg/kg/22D-I (88mg/kg)	BLOOD: LEUKOPENIA	Annals of the Rheumatic Diseases. Vol. 40, Pg. 245, 1981.
women	TDLo	oral	42mg/kg/7D-I (42mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	American Journal of Medicine. Vol. 76, Pg. 47, 1984

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4-Hydroxypyrazolo[3,4-d]pyrimidine cas no:315-30-0

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