cat |
LD |
oral |
> 50mg/kg (50mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: FOOD INTAKE (ANIMAL) |
Acta Pharmacologica et Toxicologica. Vol. 26, Pg. 343, 1968. |
dog |
LDLo |
intravenous |
22811ug/kg (22.811mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 488, 1969. |
guinea pig |
LDLo |
intravenous |
28100ug/kg (28.1mg/kg) |
? |
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980. |
man |
LDLo |
oral |
34mg/kg (34mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
CARDIAC: PULSE RATE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 781, 1988. |
man |
TDLo |
intravenous |
29ug/kg/5M-I (0.029mg/kg) |
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
Annals of Emergency Medicine. Vol. 14, Pg. 1112, 1985. |
man |
TDLo |
oral |
857ug/kg/3D-I (0.857mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Archives of Dermatology. Vol. 121, Pg. 1326, 1985. |
man |
TDLo |
oral |
4mg/kg/1W-I (4mg/kg) |
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: COUGH |
Drug Intelligence and Clinical Pharmacy. Vol. 16, Pg. 776, 1982. |
man |
TDLo |
oral |
43mg/kg (43mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
South African Medical Journal. Vol. 67, Pg. 1062, 1985. |
man |
TDLo |
oral |
417mg/kg/1Y-I (417mg/kg) |
LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION |
Practitioner. Vol. 229, Pg. 663, 1985. |
mouse |
LD50 |
intraperitoneal |
80mg/kg (80mg/kg) |
? |
Journal of Drug Research. Vol. 16, Pg. 171, 1985. |
mouse |
LD50 |
intravenous |
18mg/kg (18mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977. |
mouse |
LD50 |
oral |
320mg/kg (320mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968. |
mouse |
LD50 |
subcutaneous |
208mg/kg (208mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl, |
rabbit |
LD50 |
intravenous |
12500ug/kg (12.5mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977. |
rabbit |
LD50 |
oral |
600mg/kg (600mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 733, 1982. |
rat |
LD50 |
intraperitoneal |
76mg/kg (76mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: IRRITABILITY |
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 506, 1976. |
rat |
LD50 |
intravenous |
21mg/kg (21mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl, |
rat |
LD50 |
oral |
466mg/kg (466mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985. |
rat |
LD50 |
subcutaneous |
115mg/kg (115mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl, |
women |
LDLo |
intravenous |
40ug/kg (0.04mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
Archives of Internal Medicine. Vol. 144, Pg. 173, 1984. |
women |
LDLo |
oral |
64mg/kg (64mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: COMA
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE |
Acta Medica Scandinavica. Vol. 210, Pg. 137, 1981. |
women |
TDLo |
oral |
8400ug/kg/7D- (8.4mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: TOXIC PSYCHOSIS |
Clinical Toxicology. Vol. 4, Pg. 357, 1971. |
women |
TDLo |
oral |
22mg/kg/4W-I (22mg/kg) |
BRAIN AND COVERINGS: ENCEPHALITIS
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Journal of Clinical Gastroenterology. Vol. 8, Pg. 74, 1986. |
women |
TDLo |
oral |
77mg/kg (77mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985. |
women |
TDLo |
oral |
160mg/kg (160mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
CARDIAC: OTHER CHANGES |
Annals of Emergency Medicine. Vol. 16, Pg. 1381, 1987.
? |