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Propranolol hydrochloride cas no:318-98-9

Synonyms: 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;

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Identification
NamePropranolol hydrochloride
CAS318-98-9
Synonyms1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;
EINECS(EC#)206-268-7
Molecular FormulaC16H21NO2.HCl
Molecular Weight295.8
Chemical Properties
AppearanceWhite powder.
storage temp2-8°C
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

A deadly human poison by intravenous route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental reproductive effects. Human systemic effects: acute pulminary edema, altered sleep time, blood pressure elevation, bronchiolar constriction, cardiac arrythmias, cardiac changes, coma, convulsions, cough, dermatitis, distorted perceptions, dyspnea, encephalitis, hallucinations, mydriasis, pulse rate increase, sensory change involving peripheral nerve, somnolence, toxic psychosis. A beta-adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 22?
R22:Harmful if swallowed.
Safety Statements: 22?
S22:Do not breathe dust.
WGK Germany: 3
RTECS of Propranolol hydrochloride (CAS NO.318-98-9): UB7525000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD oral > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FOOD INTAKE (ANIMAL)		 Acta Pharmacologica et Toxicologica. Vol. 26, Pg. 343, 1968.
dog LDLo intravenous 22811ug/kg (22.811mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 488, 1969.
guinea pig LDLo intravenous 28100ug/kg (28.1mg/kg) ? Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
man LDLo oral 34mg/kg (34mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 781, 1988.
man TDLo intravenous 29ug/kg/5M-I (0.029mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION		 Annals of Emergency Medicine. Vol. 14, Pg. 1112, 1985.
man TDLo oral 857ug/kg/3D-I (0.857mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 121, Pg. 1326, 1985.
man TDLo oral 4mg/kg/1W-I (4mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: COUGH		 Drug Intelligence and Clinical Pharmacy. Vol. 16, Pg. 776, 1982.
man TDLo oral 43mg/kg (43mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 South African Medical Journal. Vol. 67, Pg. 1062, 1985.
man TDLo oral 417mg/kg/1Y-I (417mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Practitioner. Vol. 229, Pg. 663, 1985.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg) ? Journal of Drug Research. Vol. 16, Pg. 171, 1985.
mouse LD50 intravenous 18mg/kg (18mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
mouse LD50 oral 320mg/kg (320mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
mouse LD50 subcutaneous 208mg/kg (208mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rabbit LD50 intravenous 12500ug/kg (12.5mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
rabbit LD50 oral 600mg/kg (600mg/kg) ? Drugs in Japan Vol. 6, Pg. 733, 1982.
rat LD50 intraperitoneal 76mg/kg (76mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: IRRITABILITY		 Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 506, 1976.
rat LD50 intravenous 21mg/kg (21mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat LD50 oral 466mg/kg (466mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985.
rat LD50 subcutaneous 115mg/kg (115mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
women LDLo intravenous 40ug/kg (0.04mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 Archives of Internal Medicine. Vol. 144, Pg. 173, 1984.
women LDLo oral 64mg/kg (64mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: COMA

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE		 Acta Medica Scandinavica. Vol. 210, Pg. 137, 1981.
women TDLo oral 8400ug/kg/7D- (8.4mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS		 Clinical Toxicology. Vol. 4, Pg. 357, 1971.
women TDLo oral 22mg/kg/4W-I (22mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Clinical Gastroenterology. Vol. 8, Pg. 74, 1986.
women TDLo oral 77mg/kg (77mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985.
women TDLo oral 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

CARDIAC: OTHER CHANGES		 Annals of Emergency Medicine. Vol. 16, Pg. 1381, 1987.
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