318-98-9|Propranolol hydrochlorideProducts Supply - Chemical intermediates Network

Propranolol hydrochloride cas no:318-98-9

Synonyms: 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;

Identification

NamePropranolol hydrochloride
CAS318-98-9
Synonyms1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;
EINECS(EC#)206-268-7
Molecular FormulaC₁₆H₂₁NO₂^.HCl
Molecular Weight295.8

Chemical Properties

AppearanceWhite powder.
storage temp2-8°C

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

A deadly human poison by intravenous route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental reproductive effects. Human systemic effects: acute pulminary edema, altered sleep time, blood pressure elevation, bronchiolar constriction, cardiac arrythmias, cardiac changes, coma, convulsions, cough, dermatitis, distorted perceptions, dyspnea, encephalitis, hallucinations, mydriasis, pulse rate increase, sensory change involving peripheral nerve, somnolence, toxic psychosis. A beta-adrenergic blocker. When heated to decomposition it emits very toxic fumes of NO_x and HCl.
Hazard Codes:? Harmful Xn, Irritant Xi
Risk Statements: 22?
R22:Harmful if swallowed.
Safety Statements: 22?
S22:Do not breathe dust.
WGK Germany: 3
RTECS of Propranolol hydrochloride (CAS NO.318-98-9): UB7525000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	oral	> 50mg/kg (50mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: FOOD INTAKE (ANIMAL)	Acta Pharmacologica et Toxicologica. Vol. 26, Pg. 343, 1968.
dog	LDLo	intravenous	22811ug/kg (22.811mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 488, 1969.
guinea pig	LDLo	intravenous	28100ug/kg (28.1mg/kg)	?	Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
man	LDLo	oral	34mg/kg (34mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 781, 1988.
man	TDLo	intravenous	29ug/kg/5M-I (0.029mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Emergency Medicine. Vol. 14, Pg. 1112, 1985.
man	TDLo	oral	857ug/kg/3D-I (0.857mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Archives of Dermatology. Vol. 121, Pg. 1326, 1985.
man	TDLo	oral	4mg/kg/1W-I (4mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: COUGH	Drug Intelligence and Clinical Pharmacy. Vol. 16, Pg. 776, 1982.
man	TDLo	oral	43mg/kg (43mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	South African Medical Journal. Vol. 67, Pg. 1062, 1985.
man	TDLo	oral	417mg/kg/1Y-I (417mg/kg)	LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION	Practitioner. Vol. 229, Pg. 663, 1985.
mouse	LD50	intraperitoneal	80mg/kg (80mg/kg)	?	Journal of Drug Research. Vol. 16, Pg. 171, 1985.
mouse	LD50	intravenous	18mg/kg (18mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
mouse	LD50	oral	320mg/kg (320mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
mouse	LD50	subcutaneous	208mg/kg (208mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rabbit	LD50	intravenous	12500ug/kg (12.5mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
rabbit	LD50	oral	600mg/kg (600mg/kg)	?	Drugs in Japan Vol. 6, Pg. 733, 1982.
rat	LD50	intraperitoneal	76mg/kg (76mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: IRRITABILITY	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 506, 1976.
rat	LD50	intravenous	21mg/kg (21mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat	LD50	oral	466mg/kg (466mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985.
rat	LD50	subcutaneous	115mg/kg (115mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
women	LDLo	intravenous	40ug/kg (0.04mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Archives of Internal Medicine. Vol. 144, Pg. 173, 1984.
women	LDLo	oral	64mg/kg (64mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Acta Medica Scandinavica. Vol. 210, Pg. 137, 1981.
women	TDLo	oral	8400ug/kg/7D- (8.4mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS	Clinical Toxicology. Vol. 4, Pg. 357, 1971.
women	TDLo	oral	22mg/kg/4W-I (22mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Clinical Gastroenterology. Vol. 8, Pg. 74, 1986.
women	TDLo	oral	77mg/kg (77mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985.
women	TDLo	oral	160mg/kg (160mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA CARDIAC: OTHER CHANGES	Annals of Emergency Medicine. Vol. 16, Pg. 1381, 1987. ?

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Propranolol hydrochloride cas no:318-98-9

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