5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-,hydrate (1:2), (6R,7R)- cas no:31828-50-9

Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-,hydrate (1:2), (6R,7R)-
CAS31828-50-9
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[2-amino-2-(1,4-cyclohexadien-1-yl)acetamido]-3-methyl-8-oxo-, hydrate,D- (8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-amino-1,4-cyclohexadien-1-ylacetyl]amino]-3-methyl-8-oxo-, dihydrate,(6R,7R)- (9CI); Cefradin hydrate; Cefradine dihydrate; Cephradine dihydrate;Cephradine hydrate; Sefril hydrate; Velosef hydrate
Molecular FormulaC16H19 N3 O4 S . 2 H2 O
Molecular Weight475.58

Safety

Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by ingestion. When Sefril hydrate (CAS NO.31828-50-9) is heated to decomposition ,it emits toxic fumes of SO_x and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	700mg/kg (700mg/kg)	BEHAVIORAL: ATAXIA	Antimicrobial Agents and Chemotherapy. Vol. 3, Pg. 682, 1973.
mouse	LD50	intravenous	3gm/kg (3000mg/kg)	BEHAVIORAL: ATAXIA	Antimicrobial Agents and Chemotherapy. Vol. 3, Pg. 682, 1973.
mouse	LD50	oral	5gm/kg (5000mg/kg)		Antimicrobial Agents and Chemotherapy. Vol. 3, Pg. 682, 1973.
rat	LD50	intraperitoneal	4gm/kg (4000mg/kg)	BEHAVIORAL: ATAXIA	Antimicrobial Agents and Chemotherapy. Vol. 3, Pg. 682, 1973.
rat	LD50	oral	> 8500mg/kg (8500mg/kg)		Antimicrobial Agents and Chemotherapy. Vol. 3, Pg. 682, 1973.