5-Azacytidine cas no:320-67-2
Synonyms: Azacitidine;U 18496;4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one;Azacitidine [USAN:INN];s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl- (8CI);4-amino-1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;1,3,5-Triazin-2 (1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-;5-AZAC;2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one;s-Triazin-2 (1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-;Anitibiotic U 18496;Vidaza;4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;Mylosar;Azacytidine, 5-;1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-;4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one;Azacitidina [INN-Spanish];Prestwick_972;Ladakamycin;5-AZCR;Antibiotic U 18496;Azacitidinum [INN-Latin];4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one;5-AC;5 AZC;4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one;1,3,5-Triazin-2(1H)-one,4-amino-1-a-Dribofuranosyl-;
Name5-Azacytidine
CAS320-67-2
SynonymsAzacitidine;U 18496;4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one;Azacitidine [USAN:INN];s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl- (8CI);4-amino-1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;1,3,5-Triazin-2 (1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-;5-AZAC;2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one;s-Triazin-2 (1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-;Anitibiotic U 18496;Vidaza;4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;Mylosar;Azacytidine, 5-;1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-;4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one;Azacitidina [INN-Spanish];Prestwick_972;Ladakamycin;5-AZCR;Antibiotic U 18496;Azacitidinum [INN-Latin];4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one;5-AC;5 AZC;4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one;1,3,5-Triazin-2(1H)-one,4-amino-1-a-Dribofuranosyl-;
EINECS(EC#)206-280-2
Molecular FormulaC8H12N4O5
Molecular Weight244.21
Appearancewhite crystalline powder
alpha40 o (C=1, H2O 22 oC)
refractive index1.823
storage temp2-8°C
Hazard T:Toxic
Risk R45;R46;R22
Safety
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic data. Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: nausea, vomiting and diarrhea, reduction in white cell count (luekopenia and agranulocytosis). An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?
T
Risk Statements: 45-46-22?
R45:May cause cancer.?
R46:May cause heritable genetic damage.?
R22:Harmful if swallowed.
Safety Statements: 53-22-36/37/39-45
S53:Avoid exposure - obtain special instructions before use.?
S22:Do not breathe dust.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS of Azacitidine (CAS NO.320-67-2): XZ3017500
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| bird - wild |
LD50 |
oral |
100mg/kg (100mg/kg) |
? |
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. |
| dog |
LD50 |
intravenous |
7200ug/kg (7.2mg/kg) |
BLOOD: OTHER CHANGES |
Advances in Pharmacology and Chemotherapy. Vol. 14, Pg. 285, 1977. |
| mouse |
LD50 |
intraperitoneal |
68mg/kg (68mg/kg) |
? |
Experientia. Vol. 22, Pg. 53, 1966. |
| mouse |
LD50 |
intravenous |
229mg/kg (229mg/kg) |
BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
National Technical Information Service. Vol. PB84-211432, |
| mouse |
LD50 |
oral |
572mg/kg (572mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 19, Pg. 382, 1971. |
| quail |
LD50 |
oral |
> 100mg/kg (100mg/kg) |
? |
Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. |
| women |
TDLo |
intravenous |
500ug/kg (0.5mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 413, 1972. |
| women |
TDLo |
intravenous |
6mg/kg/10D-I (6mg/kg) |
BLOOD: LEUKOPENIA
BLOOD: AGRANULOCYTOSIS |
Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 413, 1972. |
