321-64-2|9-Acridinamine,1,2,3,4-tetrahydro-Products Supply

9-Acridinamine,1,2,3,4-tetrahydro- cas no:321-64-2

Synonyms: Acridine,9-amino-1,2,3,4-tetrahydro- (7CI,8CI); Acridine, 9-aminotetrahydro- (6CI);1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydro-9-aminoacridine;9-Amino-1,2,3,4-tetrahydroacridine; THA; Tacrine; Tetrahydroaminacrine;Tetrahydroaminocrin; Tetrahydroaminocrine

Identification

Name9-Acridinamine,1,2,3,4-tetrahydro-
CAS321-64-2
SynonymsAcridine,9-amino-1,2,3,4-tetrahydro- (7CI,8CI); Acridine, 9-aminotetrahydro- (6CI);1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydro-9-aminoacridine;9-Amino-1,2,3,4-tetrahydroacridine; THA; Tacrine; Tetrahydroaminacrine;Tetrahydroaminocrin; Tetrahydroaminocrine
EINECS(EC#)206-291-2
Molecular FormulaC13H14 N2
Molecular Weight198.29

Safety Data

Hazard T
Risk R25
Safety

Poison by ingestion, intraperitoneal, and subcutaneous routes. Mutation data reported. Human systemic effects: changes in blood cell count, fatty degeneration, liver function tests impaired. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	31mg/kg (31mg/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: ANTIPSYCHOTIC	Pharmaceutical Chemistry Journal Vol. 8, Pg. 409, 1974.
man	TDLo	oral	176mg/kg/7W-I (176mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 193, 1990.
mouse	LD50	intramuscular	29mg/kg (29mg/kg)		Drugs of the Future. Vol. 15, Pg. 126, 1990.
mouse	LD50	intraperitoneal	20mg/kg (20mg/kg)		Indian Journal of Pharmacology. Vol. 19, Pg. 44, 1987.
mouse	LD50	oral	39800ug/kg (39.8mg/kg)		Journal of Medicinal Chemistry. Vol. 31, Pg. 1278, 1988.
mouse	LD50	subcutaneous	25mg/kg (25mg/kg)		British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947.
rat	LD50	intramuscular	34mg/kg (34mg/kg)		Drugs of the Future. Vol. 15, Pg. 126, 1990.
rat	LD50	intraperitoneal	30mg/kg (30mg/kg)		Iugoslavica Physiologica et Pharmacologica Acta. Vol. 3, Pg. 43, 1967.
rat	LD50	oral	70mg/kg (70mg/kg)		Journal of Medicinal Chemistry. Vol. 38, Pg. 2802, 1995.
rat	LDLo	intravenous	20mg/kg (20mg/kg)		United States Patent Document. Vol. #5409948,
women	TDLo	oral	84mg/kg/6W-I (84mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 193, 1990.
women	TDLo	oral	294mg/kg/14W- (294mg/kg)	LIVER: FATTY LIVER DEGERATION LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Lancet. Vol. 1, Pg. 887, 1988.

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9-Acridinamine,1,2,3,4-tetrahydro- cas no:321-64-2

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