32780-64-6|Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1)Products Supply

Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1) cas no:32780-64-6

Synonyms: Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-,monohydrochloride (9CI);Salicylamide,5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride(8CI);5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamide monohydrochloride;Amipress;Ipolab;Labelol;Labracol;Normodyne;Presdate;Pressalolo;Trandate;Vescal;

Identification

NameBenzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1)
CAS32780-64-6
SynonymsBenzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-,monohydrochloride (9CI);Salicylamide,5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride(8CI);5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamide monohydrochloride;Amipress;Ipolab;Labelol;Labracol;Normodyne;Presdate;Pressalolo;Trandate;Vescal;
EINECS(EC#)251-211-1
Molecular FormulaC19H24N2O3.HCl
Molecular Weight364.87

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Human systemic effects: changes in urine composition, dermatitis, gastrointestinal changes, hepatocellular effects, jaundice, and liver function tests impaired. Used as an antihypertensive agent. When heated to decomposition it emits very toxic fumes of HCl and NO_x.

Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1500mg/kg (1500mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 6, Pg. 273, 1980.
man	LDLo	oral	1620mg/kg/27W (1620mg/kg)	GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Annals of Internal Medicine. Vol. 113, Pg. 210, 1990.
mouse	LD50	intraperitoneal	114mg/kg (114mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
mouse	LD50	intravenous	47mg/kg (47mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
mouse	LD50	oral	1450mg/kg (1450mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
rabbit	LD50	intravenous	41mg/kg (41mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
rabbit	LD50	oral	1250mg/kg (1250mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
rat	LD50	intraperitoneal	107mg/kg (107mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
rat	LD50	intravenous	53mg/kg (53mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Hokkaido Igaku Zasshi. Hokkaido Journal of Medical Science. Vol. 53, Pg. 15, 1978.
rat	LD50	oral	2114mg/kg (2114mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 6307, 1987.
women	LDLo	oral	244mg/kg/76D- (244mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Medicine. Vol. 87, Pg. 235, 1989.
women	LDLo	oral	360mg/kg/60D- (360mg/kg)		Annals of Internal Medicine. Vol. 113, Pg. 210, 1990.
women	LDLo	oral	360mg/kg/60D- (360mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED	Annals of Internal Medicine. Vol. 113, Pg. 210, 1990.
women	TDLo	oral	53mg/kg/53D-I (53mg/kg)		Annals of Internal Medicine. Vol. 113, Pg. 210, 1990.
women	TDLo	oral	53mg/kg/53D-I (53mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 113, Pg. 210, 1990.

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Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1) cas no:32780-64-6

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