33069-62-4|PaclitaxelProducts Supply - Chemical intermediates Network

Paclitaxel cas no:33069-62-4

Synonyms: 7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.; taxal; taxol a

Identification

NamePaclitaxel
CAS33069-62-4
Synonyms7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.; taxal; taxol a
EINECS(EC#)205-285-7
Molecular FormulaC47H51NO14
Molecular Weight853.92

Chemical Properties

AppearanceWhite Powder
refractive index-49 ° (C=1, MeOH)
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful
Risk R40;R41
Safety

Safety Information about? Paclitaxel (CAS NO.33069-62-4):
Hazard Codes:? Harmful Xn
Risk Statements: 37/38-41-42/43-62-68-40-48-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R37/38: Irritating to respiratory system and skin.?
R40: Limited evidence of a carcinogenic effect.
R41: Risk of serious damage to the eyes.?
R42/43: May cause sensitization by inhalation and skin contact.?
R48: Danger of serious damage to health by prolonged exposure.?
R62: Risk of impaired fertility.?
R68: Possible risk of irreversible effects.
Safety Statements: 22-26-36/37/39-45
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 1544
WGK Germany: 3
RTECS: DA8340700
F: 10-21
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	15mg/kg (15mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB83-170969,
mouse	LD50	intraperitoneal	128mg/kg (128mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. PB83-170969,
mouse	LD50	intravenous	12mg/kg (12mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Pharmaceutical Research. Vol. 4, Pg. 162, 1987.
rat	LD50	intraperitoneal	32530ug/kg (32.53mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB83-170969,
rat	LDLo	intravenous	85mg/kg (85mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Journal of Toxicological Sciences. Vol. 19(Suppl,
women	LDLo	intravenous	4995mg/kg/3H- (4995mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA	Lancet. Vol. 343, Pg. 727, 1994.

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Paclitaxel cas no:33069-62-4

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