33286-22-5|1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)-Products Supply

1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)- cas no:33286-22-5

Synonyms: 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S,3S)- (9CI); 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S-cis)-; (+)-Diltiazem hydrochloride;(2S,3S)-(+)-cis-Diltiazem hydrochloride; (S,S)-Diltiazem hydrochloride; Adizem;Altiazem; Anginyl; Angipress; Angizem; Blocalcin 60; Britiazim; Bruzem; CRD401; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Citizem; Cormax; Deltazen;Dicard; Dilacor; Dilacor XR; Diladel; Dilcardia; Dilgard; Dilpral; Dilrene;Diltiazem hydrochloride; Dilzene; Herbesser; Kaizem; Kardil; Masdil; RG 83606;Tiazac; Tildiem;d-cis-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride; d-cis-Diltiazem hydrochloride

Identification

Name1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)-
CAS33286-22-5
Synonyms1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S,3S)- (9CI); 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S-cis)-; (+)-Diltiazem hydrochloride;(2S,3S)-(+)-cis-Diltiazem hydrochloride; (S,S)-Diltiazem hydrochloride; Adizem;Altiazem; Anginyl; Angipress; Angizem; Blocalcin 60; Britiazim; Bruzem; CRD401; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Citizem; Cormax; Deltazen;Dicard; Dilacor; Dilacor XR; Diladel; Dilcardia; Dilgard; Dilpral; Dilrene;Diltiazem hydrochloride; Dilzene; Herbesser; Kaizem; Kardil; Masdil; RG 83606;Tiazac; Tildiem;d-cis-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride; d-cis-Diltiazem hydrochloride
EINECS(EC#)251-443-3
Molecular FormulaC22H26 N2 O4 S . Cl H
Molecular Weight450.97878

Chemical Properties

Appearanceodorless white powder
refractive index118 ° (C=1, H2O)
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful
Risk R22;R40
Safety

Hazard Codes:? Harmful Xn,? Irritant Xi
Risk Statements: 22-40-36/37/38
R22: Harmful if swallowed?
R40: Limited evidence of a carcinogenic effect?
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36-45-36/37-26
S36: Wear suitable protective clothing?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible)?
S36/37: Wear suitable protective clothing and gloves?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: 3249
WGK Germany: 3
RTECS: DL0310000
F: 8-10
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

dog	LDLo	intravenous	40mg/kg (40mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 4843, 1987.
man	LDLo	oral	21mg/kg (21mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Postgraduate Medical Journal. Vol. 69, Pg. 474, 1993. ?
man	TDLo	oral	3429ug/kg/2D- (3.429mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 341, Pg. 967, 1993.
man	TDLo	oral	15420ug/kg/7D (15.42mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Archives of Internal Medicine. Vol. 151, Pg. 1869, 1991. ?
man	TDLo	oral	36mg/kg/13D-I (36mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Gastroenterology. Vol. 88, Pg. 1260, 1985. ?
mouse	LD50	intraperitoneal	177mg/kg (177mg/kg)	?	Journal of Medicinal Chemistry. Vol. 29, Pg. 820, 1986.
mouse	LD50	intravenous	58mg/kg (58mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC	Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972. ?
mouse	LD50	oral	508mg/kg (508mg/kg)	?	Journal of Medicinal Chemistry. Vol. 33, Pg. 2192, 1990.
mouse	LD50	subcutaneous	260mg/kg (260mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC	Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972. ?
rat	LD50	intravenous	38mg/kg (38mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TETANY	Japan Medical Gazette. Vol. 11(1), Pg. 12, 1974.
rat	LD50	oral	560mg/kg (560mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC	Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972. ?
rat	LD50	subcutaneous	520mg/kg (520mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC	Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972. ?
women	LDLo	oral	120mg/kg (120mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION	Human & Experimental Toxicology. Vol. 13, Pg. 161, 1994. ?
women	TDLo	oral	7200ug/kg/2D- (7.2mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS	Journal of the Royal Society of Medicine. Vol. 81, Pg. 296, 1988.
women	TDLo	oral	7200ug/kg (7.2mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS	Journal of the Royal Society of Medicine. Vol. 81, Pg. 296, 1988.
women	TDLo	oral	8400ug/kg (8.4mg/kg)	CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Emergency Medicine. Vol. 22, Pg. 196, 1993. ?
women	TDLo	oral	18mg/kg (18mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 45, 1991. ?
women	TDLo	oral	18mg/kg (18mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 45, 1991. ?
women	TDLo	oral	19mg/kg (19mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Postgraduate Medical Journal. Vol. 64, Pg. 467, 1988. ?

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1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)- cas no:33286-22-5

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