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Home > products > 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)-

1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)- cas no:33286-22-5

Synonyms: 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S,3S)- (9CI); 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S-cis)-; (+)-Diltiazem hydrochloride;(2S,3S)-(+)-cis-Diltiazem hydrochloride; (S,S)-Diltiazem hydrochloride; Adizem;Altiazem; Anginyl; Angipress; Angizem; Blocalcin 60; Britiazim; Bruzem; CRD401; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Citizem; Cormax; Deltazen;Dicard; Dilacor; Dilacor XR; Diladel; Dilcardia; Dilgard; Dilpral; Dilrene;Diltiazem hydrochloride; Dilzene; Herbesser; Kaizem; Kardil; Masdil; RG 83606;Tiazac; Tildiem;d-cis-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride; d-cis-Diltiazem hydrochloride

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Identification
Name1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2S,3S)-
CAS33286-22-5
Synonyms1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S,3S)- (9CI); 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S-cis)-; (+)-Diltiazem hydrochloride;(2S,3S)-(+)-cis-Diltiazem hydrochloride; (S,S)-Diltiazem hydrochloride; Adizem;Altiazem; Anginyl; Angipress; Angizem; Blocalcin 60; Britiazim; Bruzem; CRD401; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Citizem; Cormax; Deltazen;Dicard; Dilacor; Dilacor XR; Diladel; Dilcardia; Dilgard; Dilpral; Dilrene;Diltiazem hydrochloride; Dilzene; Herbesser; Kaizem; Kardil; Masdil; RG 83606;Tiazac; Tildiem;d-cis-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-onehydrochloride; d-cis-Diltiazem hydrochloride
EINECS(EC#)251-443-3
Molecular FormulaC22H26 N2 O4 S . Cl H
Molecular Weight450.97878
Chemical Properties
Appearanceodorless white powder
refractive index118 ° (C=1, H2O)
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful
Risk R22;R40
Safety

Hazard Codes:?HarmfulXn,?IrritantXi
Risk Statements: 22-40-36/37/38
R22: Harmful if swallowed?
R40: Limited evidence of a carcinogenic effect?
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36-45-36/37-26
S36: Wear suitable protective clothing?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible)?
S36/37: Wear suitable protective clothing and gloves?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: 3249
WGK Germany: 3
RTECS: DL0310000
F: 8-10
HazardClass: 6.1(b)
PackingGroup: III


Toxicity

dog LDLo intravenous 40mg/kg (40mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING		 Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 4843, 1987.
man LDLo oral 21mg/kg (21mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Postgraduate Medical Journal. Vol. 69, Pg. 474, 1993.
?
man TDLo oral 3429ug/kg/2D- (3.429mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Lancet. Vol. 341, Pg. 967, 1993.
man TDLo oral 15420ug/kg/7D (15.42mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Archives of Internal Medicine. Vol. 151, Pg. 1869, 1991.
?
man TDLo oral 36mg/kg/13D-I (36mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" Gastroenterology. Vol. 88, Pg. 1260, 1985.
?
mouse LD50 intraperitoneal 177mg/kg (177mg/kg) ? Journal of Medicinal Chemistry. Vol. 29, Pg. 820, 1986.
mouse LD50 intravenous 58mg/kg (58mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972.
?
mouse LD50 oral 508mg/kg (508mg/kg) ? Journal of Medicinal Chemistry. Vol. 33, Pg. 2192, 1990.
mouse LD50 subcutaneous 260mg/kg (260mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972.
?
rat LD50 intravenous 38mg/kg (38mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TETANY		 Japan Medical Gazette. Vol. 11(1), Pg. 12, 1974.
rat LD50 oral 560mg/kg (560mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972.
?
rat LD50 subcutaneous 520mg/kg (520mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Japanese Journal of Pharmacology. Vol. 22, Pg. 467, 1972.
?
women LDLo oral 120mg/kg (120mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION Human & Experimental Toxicology. Vol. 13, Pg. 161, 1994.
?
women TDLo oral 7200ug/kg/2D- (7.2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS		 Journal of the Royal Society of Medicine. Vol. 81, Pg. 296, 1988.
women TDLo oral 7200ug/kg (7.2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS		 Journal of the Royal Society of Medicine. Vol. 81, Pg. 296, 1988.
women TDLo oral 8400ug/kg (8.4mg/kg) CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Annals of Emergency Medicine. Vol. 22, Pg. 196, 1993.
?
women TDLo oral 18mg/kg (18mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 45, 1991.
?
women TDLo oral 18mg/kg (18mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER		 Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 45, 1991.
?
women TDLo oral 19mg/kg (19mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Postgraduate Medical Journal. Vol. 64, Pg. 467, 1988.
?

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