33419-42-0|EtoposideProducts Supply - Chemical intermediates Network

Etoposide cas no:33419-42-0

Synonyms: TENIPOSIDE; 4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside); 4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside

Identification

NameEtoposide
CAS33419-42-0
SynonymsTENIPOSIDE; 4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside); 4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside
EINECS(EC#)251-509-1
Molecular FormulaC29H32O13
Molecular Weight588.55658

Chemical Properties

AppearanceWhite Crystalline Powder
refractive index-110.5 ° (C=0.6, CHCl3)
storage tempStore under refrigeration, in orginal container.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T:Toxic
Risk R45;R22
Safety

Hazard Codes of Etoposido (CAS NO.33419-42-0):? Toxic T, Irritant Xi
Risk Statements: 45-22-36/37/38
R45:May cause cancer.?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-45-36/37-26
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37:Wear suitable protective clothing and gloves.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 3249
WGK Germany: 3
RTECS: KC0190000
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	183mg/kg/2H-C (183mg/kg)	BEHAVIORAL: ATAXIA	Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 41, 1988.
human	TDLo	intravenous	2630ug/kg/10D (2.63mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: APLASTIC ANEMIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Vol. 34, Pg. 985, 1974.
human	TDLo	oral	16mg/kg/5D-I (16mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: APLASTIC ANEMIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Vol. 34, Pg. 985, 1974.
man	TDLo	intravenous	57ug/kg/2M-C (0.057mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lancet. Vol. 341, Pg. 1353, 1993.
mouse	LD50	intraperitoneal	64mg/kg (64mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
mouse	LD50	intravenous	15070ug/kg (15.07mg/kg)	?	National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	oral	215mg/kg (215mg/kg)	?	National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	subcutaneous	143mg/kg (143mg/kg)	?	Drugs in Japan Vol. -, Pg. 190, 1990.
rabbit	LD50	intravenous	37mg/kg (37mg/kg)	?	Journal of Toxicological Sciences. Vol. 11(Suppl,
rabbit	LD50	oral	147mg/kg (147mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Journal of Toxicological Sciences. Vol. 11(Suppl,
rat	LD50	intraperitoneal	39mg/kg (39mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
rat	LD50	intravenous	58mg/kg (58mg/kg)	?	Drugs in Japan Vol. -, Pg. 230, 1995.
rat	LD50	oral	1784mg/kg (1784mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
rat	LD50	subcutaneous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 190, 1990.
women	TDLo	intravenous	160ug/kg/3M-C (0.16mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lancet. Vol. 341, Pg. 1353, 1993.

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Shandong Novatech Pharmaceutical Co., Ltd.: Tel:+86-531-55582725; Address: R801,Lianggu Building, No.6 Qilihe Road,

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

Shanghai Mingdou Chemical Co.,Ltd: Tel:86-21-52912919; Address: Floor 12th, Zhenyuan Building ,No 2052.North Zhongshan Road, Shanghai,China

Shanghai Asarum Biotechnology Co., Ltd: Tel:; Address: Room 404 SiPing road No.1128 YangPu district ShangHai China

SHILPA MEDICARE LIMITED,: Tel:+0091-8532-235006, 236328; Address: 10/80, RAJENDRA GUNJ,RAICHUR - 584 102 (INDIA)

Scandinavian Formulas, Inc.: Tel:+1-215-4532507; Address: 140 E. Church St. Sellersville, PA 18960

Kingland Chemicals Company Limited: Tel:+86-571-87211518,87229835; Address: Room No. 1806-1808, Jinfeng Mansion, No.281 Zhong He Zhong Road, Hangzhou, China.

Sunji & Co., Ltd.: Tel:86-755-8825 1355 /1365 /1379; Address: Room 2103-2104, Block C , Huangdu Plaza, 3008 Yitian Road, Shenzhen 518048, P.R. of China

Lianyungang Guiyuan Chempharm Co.,Ltd.: Tel:; Address: No1,Xianfeng Road, Dapu Industry Garden, Economic development zone, Lianyungang

Shanghai Desano Pharmaceuticals Holding Co., Ltd.: Tel:; Address: No.78,887 Zuchongzhi Road,Zhangjiang High-tech Park,Shanghai,China

Melone Pharmaceutical Co., Ltd.: Tel:; Address: Room 2209锛孨o.232, Jinma Road, Development Zone, Dalian, China

FAITH EAGLE (LABORATORY) LTD.: Tel:(+86-755) 82851290; Address: 15A/F.,Block A,World Trade Plaza,8# FuHong Rd., FuTian,Shenzhen, China

Jiangsu Hengrui Medicine Co. Ltd.: Tel:+86-(518)-5473511; Address: No.145, East of Renmin Road, Xinpu District, Lianyungang, Jiangsu, Lianyungang 222002,

Zhejiang Golden Pharma Co., Limited: Tel:+86-(571)-28887955; Address: 8F-B1,Season Mansion, No.98 Gudun Road, HangZhou, Zhejiang,

Qilong Chemical Co., Ltd.: Tel:86-574-63858500; Address: No.586, Jiangnan Road,High-tech Park, Ningbo, Zhejiang 315040,

Etoposide cas no:33419-42-0

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