33419-42-0|EtoposideProducts Supply - Chemical intermediates Network

Etoposide cas no:33419-42-0

Synonyms: TENIPOSIDE; 4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside); 4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside

Identification

NameEtoposide
CAS33419-42-0
SynonymsTENIPOSIDE; 4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside); 4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside
EINECS(EC#)251-509-1
Molecular FormulaC29H32O13
Molecular Weight588.55658

Chemical Properties

AppearanceWhite Crystalline Powder
refractive index-110.5 ° (C=0.6, CHCl3)
storage tempStore under refrigeration, in orginal container.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T:Toxic
Risk R45;R22
Safety

Hazard Codes of Etoposido (CAS NO.33419-42-0):? Toxic T, Irritant Xi
Risk Statements: 45-22-36/37/38
R45:May cause cancer.?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-45-36/37-26
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37:Wear suitable protective clothing and gloves.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 3249
WGK Germany: 3
RTECS: KC0190000
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	183mg/kg/2H-C (183mg/kg)	BEHAVIORAL: ATAXIA	Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 41, 1988.
human	TDLo	intravenous	2630ug/kg/10D (2.63mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: APLASTIC ANEMIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Vol. 34, Pg. 985, 1974.
human	TDLo	oral	16mg/kg/5D-I (16mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: APLASTIC ANEMIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Vol. 34, Pg. 985, 1974.
man	TDLo	intravenous	57ug/kg/2M-C (0.057mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lancet. Vol. 341, Pg. 1353, 1993.
mouse	LD50	intraperitoneal	64mg/kg (64mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
mouse	LD50	intravenous	15070ug/kg (15.07mg/kg)	?	National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	oral	215mg/kg (215mg/kg)	?	National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	subcutaneous	143mg/kg (143mg/kg)	?	Drugs in Japan Vol. -, Pg. 190, 1990.
rabbit	LD50	intravenous	37mg/kg (37mg/kg)	?	Journal of Toxicological Sciences. Vol. 11(Suppl,
rabbit	LD50	oral	147mg/kg (147mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Journal of Toxicological Sciences. Vol. 11(Suppl,
rat	LD50	intraperitoneal	39mg/kg (39mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
rat	LD50	intravenous	58mg/kg (58mg/kg)	?	Drugs in Japan Vol. -, Pg. 230, 1995.
rat	LD50	oral	1784mg/kg (1784mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 3473, 1985.
rat	LD50	subcutaneous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 190, 1990.
women	TDLo	intravenous	160ug/kg/3M-C (0.16mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lancet. Vol. 341, Pg. 1353, 1993.

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Etoposide cas no:33419-42-0

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