33564-30-6|Cefoxitin sodiumProducts Supply - Chemical intermediates Network

Cefoxitin sodium cas no:33564-30-6

Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R,7S)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R-cis)-;Betacef;Cefaxilin sodium;Cefoxitin sodium salt;Cenomycin;Farmoxin;MK 306;Mefoxin;Mefoxithin;Mefoxitin;Merxin;Monosodium cefoxitin;Serviflox;Sodium cefoxitin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,sodium salt (1:1), (6R,7S)-;

Identification

NameCefoxitin sodium
CAS33564-30-6
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R,7S)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R-cis)-;Betacef;Cefaxilin sodium;Cefoxitin sodium salt;Cenomycin;Farmoxin;MK 306;Mefoxin;Mefoxithin;Mefoxitin;Merxin;Monosodium cefoxitin;Serviflox;Sodium cefoxitin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,sodium salt (1:1), (6R,7S)-;
EINECS(EC#)251-574-6
Molecular FormulaC₁₆H₁₆N₃NaO₇S₂
Molecular Weight449.43

Chemical Properties

AppearanceWhite to almost white powder
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass9

Safety Data

Hazard Xn:Harmful
Risk R36/37/38;R42/43
Safety

Mildly toxic by ingestion subcutaneous, and intravenous routes. Human systemic effects: aplastic anemia, interstitial nephritis, normocytic anemia. When heated to decomposition it emits toxic fumes of SO_x, NO_x, and Na₂O.
Safety Information of Cefoxitin sodium (CAS NO.33564-30-6):
Hazard Codes:? Harmful Xn, Irritant Xi
RIDADR: 3077
WGK Germany: 3
HazardClass: 9?
RTECS: XI0330500
Risk Statements: 36/37/38-42/43?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37-36/37/39
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	10000mg/kg (10000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 410, 1982.
man	TDLo	intravenous	100mg/kg/2D-I (100mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	Southern Medical Journal. Vol. 80, Pg. 274, 1987.
man	TDLo	intravenous	229mg/kg/4D-I (229mg/kg)	BLOOD: NORMOCYTIC ANEMIA BLOOD: APLASTIC ANEMIA	Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 816, 1983.
mouse	LD50	intravenous	4970mg/kg (4970mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 291, 1980.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	?	Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980.
mouse	LD50	subcutaneous	9250mg/kg (9250mg/kg)	?	Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980.
rat	LD50	intravenous	8580mg/kg (8580mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 123, 1980.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	?	Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980.

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Cefoxitin sodium cas no:33564-30-6

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