Cefoxitin sodium cas no:33564-30-6
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R,7S)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R-cis)-;Betacef;Cefaxilin sodium;Cefoxitin sodium salt;Cenomycin;Farmoxin;MK 306;Mefoxin;Mefoxithin;Mefoxitin;Merxin;Monosodium cefoxitin;Serviflox;Sodium cefoxitin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,sodium salt (1:1), (6R,7S)-;
NameCefoxitin sodium
CAS33564-30-6
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R,7S)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt, (6R-cis)-;Betacef;Cefaxilin sodium;Cefoxitin sodium salt;Cenomycin;Farmoxin;MK 306;Mefoxin;Mefoxithin;Mefoxitin;Merxin;Monosodium cefoxitin;Serviflox;Sodium cefoxitin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,sodium salt (1:1), (6R,7S)-;
EINECS(EC#)251-574-6
Molecular FormulaC16H16N3NaO7S2
Molecular Weight449.43
AppearanceWhite to almost white powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass9
Hazard Xn:Harmful
Risk R36/37/38;R42/43
Safety
Mildly toxic by ingestion subcutaneous, and intravenous routes. Human systemic effects: aplastic anemia, interstitial nephritis, normocytic anemia. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
Safety Information of Cefoxitin sodium (CAS NO.33564-30-6):
Hazard Codes:?
Xn,
Xi
RIDADR: 3077
WGK Germany: 3
HazardClass: 9?
RTECS: XI0330500
Risk Statements: 36/37/38-42/43?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37-36/37/39
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
10000mg/kg (10000mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 410, 1982. |
| man |
TDLo |
intravenous |
100mg/kg/2D-I (100mg/kg) |
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS |
Southern Medical Journal. Vol. 80, Pg. 274, 1987. |
| man |
TDLo |
intravenous |
229mg/kg/4D-I (229mg/kg) |
BLOOD: NORMOCYTIC ANEMIA
BLOOD: APLASTIC ANEMIA |
Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 816, 1983. |
| mouse |
LD50 |
intravenous |
4970mg/kg (4970mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 291, 1980. |
| mouse |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980. |
| mouse |
LD50 |
subcutaneous |
9250mg/kg (9250mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980. |
| rat |
LD50 |
intravenous |
8580mg/kg (8580mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980. |
| rat |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 123, 1980. |
| rat |
LD50 |
subcutaneous |
> 10gm/kg (10000mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 31, Pg. 629, 1980. |
