Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (11b,16a)- cas no:33755-46-3
Synonyms: Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 17-valerate (8CI); DV17; Dexamethasone 17-valerate; Dexamethasone valerate
NamePregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (11b,16a)-
CAS33755-46-3
SynonymsPregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 17-valerate (8CI); DV17; Dexamethasone 17-valerate; Dexamethasone valerate
EINECS(EC#)251-669-2
Molecular FormulaC27H37 F O6
Molecular Weight476.64
refractive index1.56
Safety
Poison by subcutaneous route. Moderately toxic by skin contact. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F−.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
oral |
> 3gm/kg (3000mg/kg) |
|
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982. |
| mouse |
LD50 |
skin |
1784mg/kg (1784mg/kg) |
|
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982. |
| mouse |
LD50 |
subcutaneous |
238mg/kg (238mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS |
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982. |
| rabbit |
LD50 |
subcutaneous |
100mg/kg (100mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| rat |
LD50 |
oral |
> 3gm/kg (3000mg/kg) |
|
Drugs in Japan Vol. -, Pg. 662, 1990. |
| rat |
LD50 |
subcutaneous |
117mg/kg (117mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
