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Temephos cas no:3383-96-8

Synonyms: Phosphorothioicacid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol (7CI);Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester(9CI);Phosphorothioic acid, O,O'-(thiodi-p-phenylene) O,O,O',O'-tetramethylester (8CI);AC 52160;Abate;Abathion;Azai-SS;Biothion;Biothon;Difenphos;Difos;Diphos;Diphos (pesticide);EI 52160;ENT 27165;Ecopro 1707;Experimental Insecticide 52,160;Lavifos;Mosq;Nephis;Nephis 1G;O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate;Procida;Temefos;Phosphorothioic acid,Op,Op'-(thiodi-4,1-phenylene) Op,Op,Op',Op'-tetramethyl ester;

Identification
NameTemephos
CAS3383-96-8
SynonymsPhosphorothioicacid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol (7CI);Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester(9CI);Phosphorothioic acid, O,O'-(thiodi-p-phenylene) O,O,O',O'-tetramethylester (8CI);AC 52160;Abate;Abathion;Azai-SS;Biothion;Biothon;Difenphos;Difos;Diphos;Diphos (pesticide);EI 52160;ENT 27165;Ecopro 1707;Experimental Insecticide 52,160;Lavifos;Mosq;Nephis;Nephis 1G;O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate;Procida;Temefos;Phosphorothioic acid,Op,Op'-(thiodi-4,1-phenylene) Op,Op,Op',Op'-tetramethyl ester;
EINECS(EC#)222-191-1
Molecular FormulaC16H20O6P2S3
Molecular Weight466.48
Chemical Properties
AppearanceWhite crystalline solid or liquid.
refractive index1.612
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard Xi: Irritant;N: Dangerous for the environment;
Risk R21/22
Safety

Hazard Codes: HarmfulXn,DangerousN
Risk Statements: 21/22-51/53
R21/22:Harmful in contact with skin and if swallowed. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 22-37-61-60 
S22:Do not breathe dust. 
S37:Wear suitable gloves. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S60:This material and its container must be disposed of as hazardous waste.
RIDADR: UN 3077
RTECS: TF6890000
Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and skin contact routes. An experimental teratogen. A skin irritant. A cholinesterase inhibitor type of insecticide. When heated to decomposition it emits toxic fumes of POx and SOx. See also Parathion.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 32mg/kg (32mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
chicken LD subcutaneous > 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Archives of Environmental Health. Vol. 14, Pg. 283, 1967.
duck LD50 oral 79mg/kg (79mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
mammal (species unspecified) LD50 oral 4700mg/kg (4700mg/kg)   Journal of the American Veterinary Medical Association. Vol. 152, Pg. 282, 1968.
mammal (species unspecified) LD50 unreported 4gm/kg (4000mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 338, 1971.
mouse LD50 intraperitoneal 683mg/kg (683mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
mouse LD50 oral 223mg/kg (223mg/kg)   Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 1, 1966.
pigeon LD50 oral 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
quail LD50 oral 75mg/kg (75mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 oral 313mg/kg (313mg/kg)   Veterinariya. Veterinary Science. Vol. 60(11), Pg. 63, 1984.
rabbit LD50 skin 970mg/kg (970mg/kg)   Toxicological Information on Cyanamid Insecticides. Vol. 8/1966,
rat LD50 intraperitoneal 912mg/kg (912mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
rat LD50 oral 1gm/kg (1000mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 493, 1973.
rat LD50 skin 1370mg/kg (1370mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 subcutaneous 2302mg/kg (2302mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 297, 1969.
rat LD50 unreported 8600mg/kg (8600mg/kg)   Travaux de la Societe de Pharmacie de Montpellier. Vol. 37(1), Pg. 45, 1977.

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