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Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)- cas no:34031-32-8

Synonyms: Gold,(1-thio-b-D-glucopyranosato)(triethylphosphine)-,2,3,4,6-tetraacetate (8CI); Gold, (1-thio-b-D-glucopyranose2,3,4,6-tetraacetato-S)(triethylphosphine)-; b-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, goldcomplex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran;SKF 39162; SKF 39162D; [(Tetra-O-acetyl-b-D-glucopyranosyl)thio](triethylphosphine)gold

Identification
NameGold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-
CAS34031-32-8
SynonymsGold,(1-thio-b-D-glucopyranosato)(triethylphosphine)-,2,3,4,6-tetraacetate (8CI); Gold, (1-thio-b-D-glucopyranose2,3,4,6-tetraacetato-S)(triethylphosphine)-; b-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, goldcomplex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran;SKF 39162; SKF 39162D; [(Tetra-O-acetyl-b-D-glucopyranosyl)thio](triethylphosphine)gold
EINECS(EC#)251-801-9
Molecular FormulaC20H34 Au O9 P S
Molecular Weight678.48
Chemical Properties
AppearanceNeedles.
Safety Data

Safety

Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from stomach. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and POx. See also GOLD COMPOUNDS.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 3200ug/kg (3.2mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
man TDLo oral 1200ug/kg/2W- (1.2mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Journal of Rheumatology. Vol. 13, Pg. 228, 1986.
mouse LD50 intraperitoneal 33800ug/kg (33.8mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 intravenous 22600ug/kg (22.6mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 oral 84940ug/kg (84.94mg/kg)   Bollettino Chimico Farmaceutico. Vol. 128, Pg. 22, 1989.
mouse LD50 subcutaneous 53600ug/kg (53.6mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intraperitoneal 25500ug/kg (25.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intravenous 39mg/kg (39mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 oral 265mg/kg (265mg/kg)   Veterinary Pathology. Vol. 15(Suppl,
rat LD50 subcutaneous 235mg/kg (235mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
women TDLo oral 5400ug/kg/10D (5.4mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Arthritis and Rheumatism. Vol. 27, Pg. 1316, 1984.

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