Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)- cas no:34031-32-8
Synonyms: Gold,(1-thio-b-D-glucopyranosato)(triethylphosphine)-,2,3,4,6-tetraacetate (8CI); Gold, (1-thio-b-D-glucopyranose2,3,4,6-tetraacetato-S)(triethylphosphine)-; b-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, goldcomplex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran;SKF 39162; SKF 39162D; [(Tetra-O-acetyl-b-D-glucopyranosyl)thio](triethylphosphine)gold
NameGold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-
CAS34031-32-8
SynonymsGold,(1-thio-b-D-glucopyranosato)(triethylphosphine)-,2,3,4,6-tetraacetate (8CI); Gold, (1-thio-b-D-glucopyranose2,3,4,6-tetraacetato-S)(triethylphosphine)-; b-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, goldcomplex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran;SKF 39162; SKF 39162D; [(Tetra-O-acetyl-b-D-glucopyranosyl)thio](triethylphosphine)gold
EINECS(EC#)251-801-9
Molecular FormulaC20H34 Au O9 P S
Molecular Weight678.48
AppearanceNeedles.
Safety
Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from stomach. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and POx. See also GOLD COMPOUNDS.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
3200ug/kg (3.2mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| man |
TDLo |
oral |
1200ug/kg/2W- (1.2mg/kg) |
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH |
Journal of Rheumatology. Vol. 13, Pg. 228, 1986. |
| mouse |
LD50 |
intraperitoneal |
33800ug/kg (33.8mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| mouse |
LD50 |
intravenous |
22600ug/kg (22.6mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| mouse |
LD50 |
oral |
84940ug/kg (84.94mg/kg) |
|
Bollettino Chimico Farmaceutico. Vol. 128, Pg. 22, 1989. |
| mouse |
LD50 |
subcutaneous |
53600ug/kg (53.6mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| rat |
LD50 |
intraperitoneal |
25500ug/kg (25.5mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| rat |
LD50 |
intravenous |
39mg/kg (39mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| rat |
LD50 |
oral |
265mg/kg (265mg/kg) |
|
Veterinary Pathology. Vol. 15(Suppl, |
| rat |
LD50 |
subcutaneous |
235mg/kg (235mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
| women |
TDLo |
oral |
5400ug/kg/10D (5.4mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS
BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Arthritis and Rheumatism. Vol. 27, Pg. 1316, 1984. |
