Ethanamine,N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride (1:1) cas no:341-69-5

NameEthanamine,N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride (1:1)
CAS341-69-5
SynonymsEthanamine,N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride (9CI);Ethylamine, N,N-dimethyl-2-[(o-methyl-a-phenylbenzyl)oxy]-, hydrochloride (8CI); (?à)-Orphenadrine hydrochloride;2-(Dimethylamino)ethyl 2-methylbenzhydryl ether hydrochloride; Brocasipal;Disipal; Disipal hydrochloride; Mebedrol; Mefenamin hydrochloride; Mephenamin;Mephenamin hydrochloride; Mephenamine; Mephenamine hydrochloride;N,N-Dimethyl-2-(o-methyl-a-phenylbenzyloxy)ethylamine hydrochloride; NSC 82357; Orfenadrinhydrochloride; Orphenadrine hydrochloride
EINECS(EC#)206-435-4
Molecular FormulaC18H23 N O . Cl H
Molecular Weight305.88

Appearancewhite crystalline powder
storage temp2-8°C

Hazardclass6.1(b)

Hazard Xn
Risk R22
Safety

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis (pupillary dilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl. 
Hazard Codes:
Xn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
RIDADR: 3249
RTECS: KR6300000
HazardClass: 6.1(b)
PackingGroup: III

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	33mg/kg (33mg/kg)	brain and coverings: increased intracranial pressure	Archiv fuer Toxikologie. Vol. 25, Pg. 76, 1969.
guinea pig	LD50	subcutaneous	74mg/kg (74mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 373, 1972.
man	TDLo	oral	71mg/kg (71mg/kg)	sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: "hallucinations, distorted perceptions" cardiac: pulse rate increase without fall in bp	Human Toxicology. Vol. 4, Pg. 331, 1985.
mouse	LD50	intraperitoneal	65mg/kg (65mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 373, 1972.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: changes in motor activity (specific assay) behavioral: ataxia	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
mouse	LD50	oral	100mg/kg (100mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: changes in motor activity (specific assay) behavioral: ataxia	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
mouse	LD50	subcutaneous	88mg/kg (88mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 373, 1972.
rat	LD50	intraperitoneal	93mg/kg (93mg/kg)	lungs, thorax, or respiration: respiratory stimulation	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
rat	LD50	intravenous	27500ug/kg (27.5mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: changes in motor activity (specific assay) behavioral: ataxia	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
rat	LD50	oral	255mg/kg (255mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: convulsions or effect on seizure threshold behavioral: tremor	Gendai no Rinsho. Vol. 2, Pg. 311, 1968.
rat	LD50	subcutaneous	230mg/kg (230mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: ataxia behavioral: changes in motor activity (specific assay)	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
women	TDLo	oral	150mg/kg (150mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: coma lungs, thorax, or respiration: dyspnea	Archiv fuer Toxikologie. Vol. 23, Pg. 264, 1968.