34140-59-5|Trimebutine maleateProducts Supply - Chemical intermediates Network

Trimebutine maleate cas no:34140-59-5

Synonyms: Cerekinon;dimethyl-[2-phenyl-1-(3,4,5-trimethoxybenzoyl)oxy-butan-2-yl]azanium; 4-hydroxy-4-oxo-but-2-enoate;TM 906;Trimebutine maleate (JP14);Cerekinon (TN);

Identification

NameTrimebutine maleate
CAS34140-59-5
SynonymsCerekinon;dimethyl-[2-phenyl-1-(3,4,5-trimethoxybenzoyl)oxy-butan-2-yl]azanium; 4-hydroxy-4-oxo-but-2-enoate;TM 906;Trimebutine maleate (JP14);Cerekinon (TN);
EINECS(EC#)251-845-9
Molecular FormulaC₂₆H₃₃NO₉
Molecular Weight503.54

Chemical Properties

AppearanceWhite solid
storage temp2-8°C

Safety Data

Hazard C
Risk R34
Safety An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI0360000

CAS REGISTRY NUMBER :: 34140-59-5

LAST UPDATED :: 199507

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C22-H29-N-O5.C4-H4-O4

MOLECULAR WEIGHT :: 503.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5500 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 625 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3250 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6500 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982

supplier list

Saniver Limited: Tel:; Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong.

CNCCC SICHUAN IMPORT/EXPORT CO.,LTD.: Tel:; Address: 8C Ruili, Palm Garden, 153 KeHua North Rd, Chengdu,Sichuan, P.R.China

INFA S.P.A.: Tel:+39-02-777281; Address: Via Salvini 10, 20122 Milan (Italy)

EASYBUYER LTD.,: Tel:+86-21-35015877 +86-13701868511; Address: Room 407, Building 10, Hi-Shanghai Center, No.990 Dalian Rd,Shanghai 200092 China

Changzhou ComWin Fine Chemicals Co.,Ltd.: Tel:; Address: 24th Floor, Jiaye International Commercial Plaza, 99 Yanling West Road, Changzhou, Jiangsu, China

SUNWELL CHEMICALS CO.,LTD.(INTERPHARMA TRADING CO...: Tel:; Address: SUITE 1108,GOLDEN PLAZA,NO.118,QING CHUN ROAD,HANGZHOU,ZHEJIANG,CHINA

SINOCHEM NINGBO LTD.: Tel:86-574-87260209 87348868; Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China

Zhejiang Haisen Pharmaceutical Co., Ltd.: Tel:86-579-86768615; Address: LIUSHI TOWN, DONGYANG CITY, ZHEJIANG

Maxpharm Group: Tel:; Address: B-24AB, Qingnian Plaza, Wuhan, 430022, China

Sunji & Co., Ltd.: Tel:86-755-8825 1355 /1365 /1379; Address: Room 2103-2104, Block C , Huangdu Plaza, 3008 Yitian Road, Shenzhen 518048, P.R. of China

Tianjin Dongpeng Industry & Trade Co.,Ltd: Tel:; Address:

Sunasia Co., Ltd.: Tel:; Address: Suite 1503, 15Fl., Huijin Mansion, No. 77 He Yi Road, Ningbo 315000 China

IHWA CO., LTD: Tel:+82-2-752-5125; Address: NO. 705, THE SHARP OFFICE, 151, SUNHWA-DONG, JUNG-GU, SEOUL, KOREA

Laboratoire SUBSTIPHARM: Tel:; Address:

N-Techem International Co.Ltd.: Tel:; Address: Room 803, B Building, LiYuanShangDu, 39#, 158 Lane, HuanCheng XiLu, Ningbo, Zhejiang, China

Trimebutine maleate cas no:34140-59-5

Directory

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

supplier list