34183-22-7|1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1)Products Supply

1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1) cas no:34183-22-7

Synonyms: 1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride(8CI);Arythmol;Pronon;Rythmol;Rytmonorm;

Identification

Name1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1)
CAS34183-22-7
Synonyms1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride(8CI);Arythmol;Pronon;Rythmol;Rytmonorm;
EINECS(EC#)251-867-9
Molecular FormulaC₂₁H₂₈ClNO₃
Molecular Weight377.91

Chemical Properties

AppearanceWhite solid
storage temp2-8°C

Safety Data

Hazard T: Toxic;
Risk R46
Safety

Hazard Codes of Prorafenone Hydrochloride (CAS NO.34183-22-7):? Toxic T, Harmful Xn
Risk Statements: 46-22?
R46: May cause heritable genetic damage.?
R22: Harmful if swallowed.
Safety Statements: 53-36/37/39-45?
S53: Avoid exposure - obtain special instructions before use.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS UH2833000
Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects: paresthesia, wakefulness, hallucinations, distorted perceptions, pulse rate increase. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	oral	60mg/kg (60mg/kg)	?	Cardiac Arrhythmias: Diagnosis, Prognosis, Therapy; Proceedings International Rytmonorm- Congress. Vol. 1, Pg. 103, 1983.
child	TDLo	oral	133mg/kg (133mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CHANGE IN CONDUCTION VELOCITY	Annals of Emergency Medicine. Vol. 16, Pg. 437, 1987.
dog	LD50	intravenous	10mg/kg (10mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1849, 1976.
mammal (species unspecified)	LD50	subcutaneous	200mg/kg (200mg/kg)	?	Ceska a Slovenska Farmacie. Vol. 47, Pg. 179, 1998.
man	LDLo	oral	4286ug/kg/15H (4.286mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Postgraduate Medical Journal. Vol. 60, Pg. 155, 1984.
man	TDLo	oral	53571ug/kg (53.571mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE GASTROINTESTINAL: OTHER CHANGES	Deutsche Medizinische Wochenschrift. Vol. 116, Pg. 1573, 1991.
man	TDLo	oral	2346mg/kg/1Y- (2346mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE	Mayo Clinic Proceedings. Vol. 70, Pg. 469, 1995.
mouse	LD50	intraperitoneal	79mg/kg (79mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
mouse	LD50	intravenous	25mg/kg (25mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
mouse	LD50	oral	341mg/kg (341mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
mouse	LD50	subcutaneous	100mg/kg (100mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
rat	LD50	intraperitoneal	59mg/kg (59mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
rat	LD50	intravenous	18800ug/kg (18.8mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1849, 1976.
rat	LD50	oral	700mg/kg (700mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1849, 1976.
rat	LD50	subcutaneous	156mg/kg (156mg/kg)	?	Drugs in Japan Vol. -, Pg. 1035, 1990.
women	TDLo	oral	12mg/kg/1D-I (12mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: WAKEFULNESS BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Journal of Clinical Psychiatry. Vol. 46, Pg. 104, 1985.

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1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1) cas no:34183-22-7

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