2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide cas no:346-18-9

Name2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide
CAS346-18-9
Synonyms(?à)-Nephril; (?à)-Polythiazide; 2-Methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide;6-Chloro-3,4-dihydro-2-methyl-3-[[2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-7-sulfamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-1,2,4-benzothiadiazine1,1-dioxide; Drenusil; NSC 108161; Nephril; P 2525; Polythiazide; Renese
EINECS(EC#)206-468-4
Molecular FormulaC11H13 Cl F3 N3 O4 S3
Molecular Weight439.90

refractive index1.566

Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl⁻, SO_x, F⁻, and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	450mg/kg (450mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 97, 1969.
mouse	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. 793, 1982.
rat	LD50	intraperitoneal	400mg/kg (400mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 97, 1969.
rat	LD50	oral	> 10mg/kg (10mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
women	LDLo	oral	300ug/kg/5D-I (0.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	American Journal of Medicine. Vol. 70, Pg. 1163, 1981.