1-Piperazineethanol,4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-, hydrochloride (1:2) cas no:34758-84-4

Name1-Piperazineethanol,4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-, hydrochloride (1:2)
CAS34758-84-4
Synonyms1-Piperazineethanol,4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-, dihydrochloride (9CI); 3024CERM; Antituxil Z;CERM 3024; Citizeta; Mirsol; Respilene; Respirase; Zipeprol dihydrochloride;Zitoxil
EINECS(EC#)252-192-2
Molecular FormulaC23H32 N2 O3 . 2 Cl H
Molecular Weight440.46

Safety

Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NO_x and ClH.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	154mg/kg/3D-I (154mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.
dog	LD50	oral	228mg/kg (228mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
dog	LDLo	intravenous	54600ug/kg (54.6mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
human	TDLo	oral	11mg/kg (11mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Lancet. Vol. 1, Pg. 45, 1984.
man	TDLo	oral	10714ug/kg (10.714mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.
mouse	LD50	intraperitoneal	116mg/kg (116mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse	LD50	intravenous	44300mg/kg (44300mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse	LD50	oral	300mg/kg (300mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
mouse	LD50	subcutaneous	158mg/kg (158mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rabbit	LD50	oral	173mg/kg (173mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	intraperitoneal	77600ug/kg (77.6mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	intravenous	32700ug/kg (32.7mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	oral	435mg/kg (435mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	subcutaneous	139mg/kg (139mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
women	TDLo	oral	18mg/kg (18mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.