Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, hydrochloride (1:1), (5a)- cas no:357-08-4
Synonyms: Morphinan-6-one,17-allyl-4,5a-epoxy-3,14-dihydroxy-,hydrochloride (8CI);Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5a)- (9CI);Normorphinone,N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride (7CI);(-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride;(-)-Naloxonehydrochloride;EN 1530;EN 15304;N-Allyldihydro-14-hydroxynormorphinonehydrochloride;NIH 7890;Nalone;Nalonee;Narcan;Narcanti;l-Naloxone hydrochloride;
NameMorphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, hydrochloride (1:1), (5a)-
CAS357-08-4
SynonymsMorphinan-6-one,17-allyl-4,5a-epoxy-3,14-dihydroxy-,hydrochloride (8CI);Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5a)- (9CI);Normorphinone,N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride (7CI);(-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride;(-)-Naloxonehydrochloride;EN 1530;EN 15304;N-Allyldihydro-14-hydroxynormorphinonehydrochloride;NIH 7890;Nalone;Nalonee;Narcan;Narcanti;l-Naloxone hydrochloride;
EINECS(EC#)206-611-0
Molecular FormulaC19H22ClNO4
Molecular Weight327.37434
Appearancewhite to off-white/powder
storage temp2-8°C
Hazard Xi: Irritant;
Risk R36/37/38
Safety Poison by intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by intravenous route: pulse rate increase, acute pulmonary edema, sweating. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD2275000
- CHEMICAL NAME :
- Morphinan-6-one,
4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,
hydrochloride, (5-alpha)-
- CAS REGISTRY NUMBER :
- 357-08-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C19-H21-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 363.87
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P2U1
&GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 32 ug/kg/3M-C
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - acute pulmonary edema
Skin and Appendages - sweating
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 16,1294,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 13 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia,
PA) V.1- 1983- Volume(issue)/page/year: 7,127,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,655,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 239 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 16,357,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,655,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,655,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,655,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 17,255,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 286 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 20,844,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,655,1985
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 560 mg/kg
- SEX/DURATION :
- female 7-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
3,295,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 18 mg/kg
- SEX/DURATION :
- female 14-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,479,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 75 mg/kg
- SEX/DURATION :
- female 4-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
11,441,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 1800 ug/kg
- SEX/DURATION :
- lactating female 1 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
Endocrine - changes in luteinizing hormone
- REFERENCE :
- THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
V.1- 1974- Volume(issue)/page/year: 39,1193,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- lactating female 2 hour(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - endocrine system
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
39,532,1988
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5315
No. of Facilities: 152 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 10824 (estimated)
No. of Female Employees: 9407 (estimated)
