Maytansine cas no:35846-53-8
Synonyms: 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane,maytansine deriv.; L-Alanine, N-acetyl-N-methyl-,11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-ylester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-; MTS; Maitansine;Maysanine; Maytansin; N-Acetyl-N-methyl-L-alanine [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-ylester; NSC 153858
NameMaytansine
CAS35846-53-8
Synonyms4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane,maytansine deriv.; L-Alanine, N-acetyl-N-methyl-,11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-ylester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-; MTS; Maitansine;Maysanine; Maytansin; N-Acetyl-N-methyl-L-alanine [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-ylester; NSC 153858
EINECS(EC#)252-754-7
Molecular FormulaC34H46 Cl N3 O10
Molecular Weight678.27
refractive index1.59
Safety A deadly poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by intravenous route: hallucinations, distorted perceptions, change in motor activity, and nausea or vomiting. An experimental teratogen. Mutation data reported. Used as an antineoplastic agent. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
