Acepromazine maleate cas no:3598-37-6

NameAcepromazine maleate
CAS3598-37-6
Synonyms10-(3-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone maleate (1:1);A 23051;2-Acetyl-10-(3-(dimethylamino)propyl)phenothiazine, maleate;Acepromazine monomaleate;Acetylpromazine maleate (1:1);Phenothiazine, 2-acetyl-10-(3-(dimethylamino)propyl)-, maleate;Plegicil;Sedalin;Soprontin;UNII-37862HP2OM;
EINECS(EC#)222-748-9
Molecular FormulaC₁₉H₂₂N₂OS•C₄H₄O₄
Molecular Weight442.57

Appearanceoff white or yellow crystalline powder

Hazard Xn;N
Risk R22
Safety Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits highly toxic fumes of NOx and SOx. See also KETONES.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OB2450000

CAS REGISTRY NUMBER :

3598-37-6

LAST UPDATED :

199707

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C19-H22-N2-O-S.C4-H4-O4

MOLECULAR WEIGHT :

442.57

WISWESSER LINE NOTATION :

T C666 BN ISJ B3N1&1 EV1 &OV1U1VO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

6250 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP

REFERENCE :

AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,247,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

95 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

270 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

175 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

65 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1537 No. of Facilities: 315 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2207 (estimated) No. of Female Employees: 946 (estimated)