Estra-1,3,5(10)-triene-2,3,17-triol,(17b)- cas no:362-05-0

NameEstra-1,3,5(10)-triene-2,3,17-triol,(17b)-
CAS362-05-0
SynonymsEstra-1,3,5(10)-triene-2,3,17b-triol (7CI,8CI); 2,3,17b-Trihydroxyestra-1,3,5(10)-triene;2-Hydroxyestradiol; NSC 61711
Molecular FormulaC18H24 O3
Molecular Weight288.42

refractive index1.622
storage temp−20°C

Hazard Xn: Harmful;
Risk 40
Safety

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes of 2-Hydroxyestradiol (CAS NO.362-05-0): Xn
Risk Statements: 40 
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 22-36 
S22:Do not breathe dust. 
S36:Wear suitable protective clothing.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KG7675000

CHEMICAL NAME :

Estra-1,3,5(10)-triene-2,3,17-beta-triol

CAS REGISTRY NUMBER :

362-05-0

BEILSTEIN REFERENCE NO. :

2219367

LAST UPDATED :

199709

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C18-H24-O3

MOLECULAR WEIGHT :

288.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

1280 ng/kg

SEX/DURATION :

male 8 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :

ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 23,339,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

10 ug/kg

SEX/DURATION :

female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 42,165,1986