| child |
TDLo |
oral |
7143ug/kg (7.143mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BLOOD: APLASTIC ANEMIA |
South African Medical Journal. Vol. 66, Pg. 31, 1984. |
| dog |
LD50 |
oral |
108mg/kg (108mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980. |
| guinea pig |
LD50 |
oral |
388mg/kg (388mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
| hamster |
LD50 |
oral |
170mg/kg (170mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
| man |
LDLo |
oral |
3714mg/kg/13D (3714mg/kg) |
BLOOD: AGRANULOCYTOSIS
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
New England Journal of Medicine. Vol. 309, Pg. 795, 1983. |
| man |
TDLo |
oral |
52mg/kg/26W-I (52mg/kg) |
? |
Annals of Internal Medicine. Vol. 99, Pg. 282, 1983. |
| man |
TDLo |
oral |
7636mg/kg/6W- (7636mg/kg) |
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS |
American Journal of Nephrology. Vol. 5, Pg. 142, 1985. |
| monkey |
LD50 |
oral |
1gm/kg (1000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980. |
| mouse |
LD50 |
intraperitoneal |
290mg/kg (290mg/kg) |
? |
Russian Pharmacology and Toxicology Vol. 49, Pg. 98, 1986. |
| mouse |
LD50 |
oral |
250mg/kg (250mg/kg) |
? |
European Patent Application. Vol. #0079639, |
| mouse |
LD50 |
subcutaneous |
300mg/kg (300mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980. |
| rat |
LD50 |
intraperitoneal |
335mg/kg (335mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980. |
| rat |
LD50 |
oral |
216mg/kg (216mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1714, 1978. |
| rat |
LD50 |
rectal |
400mg/kg (400mg/kg) |
BEHAVIORAL: ANALGESIA |
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 87, 1981. |
| rat |
LD50 |
skin |
> 5gm/kg (5000mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 37(11), Pg. -, 1986. |
| rat |
LD50 |
subcutaneous |
148mg/kg (148mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980. |
| women |
LDLo |
oral |
2400ug/kg (2.4mg/kg) |
LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
British Medical Journal. Vol. 293, Pg. 540, 1986. |
| women |
TDLo |
oral |
400ug/kg (0.4mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Allergy. Vol. 52(Suppl, |
| women |
TDLo |
oral |
1200ug/kg/3D- (1.2mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Journal of Rheumatology. Vol. 11, Pg. 554, 1984. |
| women |
TDLo |
oral |
28mg/kg (28mg/kg) |
BEHAVIORAL: HEADACHE
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM
GASTROINTESTINAL: NAUSEA OR VOMITING |
Acta Medica Scandinavica. Vol. 216, Pg. 335, 1984.
? |
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