364-62-5|Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-Products Supply

Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- cas no:364-62-5

Synonyms: o-Anisamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]- (7CI,8CI);2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide;2-Methoxy-5-chloroprocainamide;N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-methoxybenzamide;Plasil;Primperan;Regla;4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;5-Chloro-2-methoxyprocainamide;Clopromate;DEL 1267;Draclamid;Eucil;Gastrese;Gastro-Timelets;Gastromax;Gastrosil;Gastrotem;MCP-ratiopharm;Macperan;Maxeran;Meclopran;Metamide;Metoclol;Metramid;Moriperan;N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;

Identification

NameBenzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-
CAS364-62-5
Synonymso-Anisamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]- (7CI,8CI);2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide;2-Methoxy-5-chloroprocainamide;N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-methoxybenzamide;Plasil;Primperan;Regla;4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;5-Chloro-2-methoxyprocainamide;Clopromate;DEL 1267;Draclamid;Eucil;Gastrese;Gastro-Timelets;Gastromax;Gastrosil;Gastrotem;MCP-ratiopharm;Macperan;Maxeran;Meclopran;Metamide;Metoclol;Metramid;Moriperan;N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;
EINECS(EC#)206-662-9
Molecular FormulaC₁₄H₂₂ClN₃O₂
Molecular Weight299.8

Chemical Properties

refractive index1.553

Safety Data

Safety

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion or intravenous routes: tremors, high blood pressure and abnormal catecholamine levels in the sympathetic nervous system, diplopia. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and Cl⁻.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	2mg/kg/1D-C (2mg/kg)	BEHAVIORAL: EXCITEMENT	Journal of Pediatrics. Vol. 104, Pg. 138, 1984.
child	TDLo	oral	900ug/kg (0.9mg/kg)	SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Archives of Disease in Childhood. Vol. 55, Pg. 310, 1980.
infant	TDLo	oral	3mg/kg/9H-I (3mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA	Pediatric Emergency Care. Vol. 14, Pg. 39, 1998.
man	TDLo	intravenous	14ug/kg (0.014mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Internal Medicine. Vol. 104, Pg. 125, 1986.
man	TDLo	oral	111mg/kg/37W- (111mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS	Japanese Journal of Medicine. Vol. 23, Pg. 152, 1984.
man	TDLo	oral	632mg/kg/59D- (632mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: EXCITEMENT	Journal of Clinical Psychiatry. Vol. 48, Pg. 38, 1987.
mouse	LD50	intraperitoneal	96mg/kg (96mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse	LD50	intravenous	33mg/kg (33mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse	LD50	oral	270mg/kg (270mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse	LD50	subcutaneous	190mg/kg (190mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
rabbit	LD50	intravenous	30mg/kg (30mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat	LD50	intraperitoneal	114mg/kg (114mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
rat	LD50	intravenous	50mg/kg (50mg/kg)		Bollettino Chimico Farmaceutico. Vol. 115, Pg. 649, 1976.
rat	LD50	oral	750mg/kg (750mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
rat	LD50	subcutaneous	340mg/kg (340mg/kg)		Drugs in Japan Vol. 6, Pg. 838, 1982.
women	TDLo	intravenous	2400ug/kg (2.4mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	New England Journal of Medicine. Vol. 307, Pg. 1346, 1982.
women	TDLo	oral	3600ug/kg/6D- (3.6mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Annals of Internal Medicine. Vol. 97, Pg. 621, 1982.

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Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- cas no:364-62-5

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