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Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- cas no:364-62-5

Synonyms: o-Anisamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]- (7CI,8CI);2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide;2-Methoxy-5-chloroprocainamide;N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-methoxybenzamide;Plasil;Primperan;Regla;4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;5-Chloro-2-methoxyprocainamide;Clopromate;DEL 1267;Draclamid;Eucil;Gastrese;Gastro-Timelets;Gastromax;Gastrosil;Gastrotem;MCP-ratiopharm;Macperan;Maxeran;Meclopran;Metamide;Metoclol;Metramid;Moriperan;N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;

Identification
NameBenzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-
CAS364-62-5
Synonymso-Anisamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]- (7CI,8CI);2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide;2-Methoxy-5-chloroprocainamide;N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-methoxybenzamide;Plasil;Primperan;Regla;4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;5-Chloro-2-methoxyprocainamide;Clopromate;DEL 1267;Draclamid;Eucil;Gastrese;Gastro-Timelets;Gastromax;Gastrosil;Gastrotem;MCP-ratiopharm;Macperan;Maxeran;Meclopran;Metamide;Metoclol;Metramid;Moriperan;N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;
EINECS(EC#)206-662-9
Molecular FormulaC14H22ClN3O2
Molecular Weight299.8
Chemical Properties
refractive index1.553
Safety Data

Safety

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion or intravenous routes: tremors, high blood pressure and abnormal catecholamine levels in the sympathetic nervous system, diplopia. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 2mg/kg/1D-C (2mg/kg) BEHAVIORAL: EXCITEMENT Journal of Pediatrics. Vol. 104, Pg. 138, 1984.
child TDLo oral 900ug/kg (0.9mg/kg) SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archives of Disease in Childhood. Vol. 55, Pg. 310, 1980.
infant TDLo oral 3mg/kg/9H-I (3mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Pediatric Emergency Care. Vol. 14, Pg. 39, 1998.
man TDLo intravenous 14ug/kg (0.014mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Annals of Internal Medicine. Vol. 104, Pg. 125, 1986.
man TDLo oral 111mg/kg/37W- (111mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS Japanese Journal of Medicine. Vol. 23, Pg. 152, 1984.
man TDLo oral 632mg/kg/59D- (632mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: EXCITEMENT
Journal of Clinical Psychiatry. Vol. 48, Pg. 38, 1987.
mouse LD50 intraperitoneal 96mg/kg (96mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse LD50 intravenous 33mg/kg (33mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse LD50 oral 270mg/kg (270mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
mouse LD50 subcutaneous 190mg/kg (190mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
rabbit LD50 intravenous 30mg/kg (30mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 intraperitoneal 114mg/kg (114mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
rat LD50 intravenous 50mg/kg (50mg/kg)   Bollettino Chimico Farmaceutico. Vol. 115, Pg. 649, 1976.
rat LD50 oral 750mg/kg (750mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
rat LD50 subcutaneous 340mg/kg (340mg/kg)   Drugs in Japan Vol. 6, Pg. 838, 1982.
women TDLo intravenous 2400ug/kg (2.4mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION New England Journal of Medicine. Vol. 307, Pg. 1346, 1982.
women TDLo oral 3600ug/kg/6D- (3.6mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Annals of Internal Medicine. Vol. 97, Pg. 621, 1982.

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