Tolperisone hydrochloride cas no:3644-61-9
Synonyms: 1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI);Propiophenone, 2,4'-dimethyl-3-piperidino-, hydrochloride (7CI,8CI);1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride;2,4'-Dimethyl-3-piperidinopropiophenone hydrochloride;Abbsa;Arantoick;Besnoline;Isocalm;Kineorl;Menopatol;Metosomin;Muscalm;Mydocalm;Naismeritin;Tolisartine;1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1);
NameTolperisone hydrochloride
CAS3644-61-9
Synonyms1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI);Propiophenone, 2,4'-dimethyl-3-piperidino-, hydrochloride (7CI,8CI);1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride;2,4'-Dimethyl-3-piperidinopropiophenone hydrochloride;Abbsa;Arantoick;Besnoline;Isocalm;Kineorl;Menopatol;Metosomin;Muscalm;Mydocalm;Naismeritin;Tolisartine;1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1);
EINECS(EC#)222-876-5
Molecular FormulaC16H24ClNO
Molecular Weight281.82
Appearancewhite solid
storage tempRoom temp
Hazard Xn: Harmful;Xi: Irritant;
Risk R20/21/22
Safety
Hazard Codes:?
Xn,?
Xi
Risk Statements: 20/21/22-52/53-36/37/38?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-45-61-36/37-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S36/37:Wear suitable protective clothing and gloves.?
S37/39:Wear suitable gloves and eye/face protection.
RTECS: UH1575500
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx and HCl.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD50 |
intravenous |
40mg/kg (40mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: MUSCLE WEAKNESS |
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 809, 1975. |
| dog |
LD50 |
intravenous |
45mg/kg (45mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: MUSCLE WEAKNESS |
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 809, 1975. |
| mouse |
LD50 |
intraperitoneal |
210mg/kg (210mg/kg) |
? |
United States Patent Document. Vol. #4528299, |
| mouse |
LD50 |
intravenous |
34mg/kg (34mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 24, Pg. 1637, 1973. |
| mouse |
LD50 |
oral |
358mg/kg (358mg/kg) |
? |
Yakugaku Zasshi. Journal of Pharmacy. Vol. 107, Pg. 705, 1987. |
| mouse |
LD50 |
subcutaneous |
655mg/kg (655mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 24, Pg. 1637, 1973. |
| rat |
LD50 |
intraperitoneal |
170mg/kg (170mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 531, 1982. |
| rat |
LD50 |
oral |
1450mg/kg (1450mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 531, 1982. |
| rat |
LD50 |
subcutaneous |
645mg/kg (645mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 531, 1982. |
