Melittin cas no:37231-28-0

NameMelittin
CAS37231-28-0
Synonymsmelittinfrombeevenomsequencing*grade;melittinhoneybeevenom;melittin-t;MELLITIN;MELITTIN;MELITTIN (NATURAL);GIGAVLKVLTTGLPALISWIKRKRQQ-NH2;H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
EINECS(EC#)253-417-7
Molecular FormulaC131H229N39O31
Molecular Weight2846.99

Appearancesolid
storage temp2-8°C

Hazard T: Toxic;Xn: Harmful;
Risk R23/24/25
Safety

Poison by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. A major component of bee venom.
Safety Information of Mellitin (CAS NO.37231-28-0):
Hazard Codes: T,Xn
Risk Statements: 23/24/25-21/22
21:  Harmful in contact with skin 
22:  Harmful if swallowed 
23:  Toxic by inhalation 
24:  Toxic in contact with skin 
25:  Toxic if swallowed 
Safety Statements: 36
36:  Wear suitable protective clothing  

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraarterial	400ug/kg (0.4mg/kg)		Toxicon. Vol. 13, Pg. 277, 1975.
cat	LDLo	intravenous	6mg/kg (6mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Toxicon. Vol. 13, Pg. 277, 1975.
mouse	LD50	intracrebral	860ug/kg (0.86mg/kg)		Toxicon. Vol. 22, Pg. 308, 1984.
mouse	LD50	intraperitoneal	5mg/kg (5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1921, 1972.
mouse	LD50	intravenous	3500ug/kg (3.5mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley, eds., 3 vols., New York, Academic Press, Inc., 1968-71Vol. 3, Pg. 61, 1971.
mouse	LD50	parenteral	2500ug/kg (2.5mg/kg)		Toxicon. Vol. 12, Pg. 139, 1974.