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Metoprolol cas no:37350-58-6

Synonyms: Metroprolol; 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol

Identification
NameMetoprolol
CAS37350-58-6
SynonymsMetroprolol; 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol
EINECS(EC#)253-483-7
Molecular FormulaC15H25NO3
Molecular Weight267.37
Safety Data

Safety

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiac, eye, and behavioral effects. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 60mg/kg (60mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 186, 1979.
mouse LD50 intraperitoneal > 200mg/kg (200mg/kg)   Farmaco, Edizione Scientifica. Vol. 41, Pg. 80, 1986.
mouse LD50 intravenous 62mg/kg (62mg/kg)   United States Patent Document. Vol. #4252984,
mouse LD50 oral 1050mg/kg (1050mg/kg)   United States Patent Document. Vol. #4252984,
mouse LD50 subcutaneous > 600mg/kg (600mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 50, Pg. 2289, 1985.
rat LD50 intravenous 71900ug/kg (71.9mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977.
rat LD50 oral 3470mg/kg (3470mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977.
women TDLo oral 17mg/kg/17D-I (17mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: EXCITEMENT
Annals of Internal Medicine. Vol. 108, Pg. 67, 1988.
women TDLo oral 150mg/kg (150mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SLEEP

CARDIAC: CHANGE IN FORCE OF CONTRACTION
Acta Medica Scandinavica. Vol. 218, Pg. 525, 1985.

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