2-Pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl- cas no:3737-09-5

Name2-Pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl-
CAS3737-09-5
Synonyms2-Pyridineacetamide,a-[2-(diisopropylamino)ethyl]-a-phenyl- (7CI,8CI);(RS)-disopyramide; (?à)-Disopyramide; 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide;Dicorantil; Disopyramide; H 3292; Isorythm; Lispine; Ritmilen; Ritmodan; SC7031; Searle 703; dl-Disopyramide; a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide
EINECS(EC#)223-110-2
Molecular FormulaC21H29 N3 O
Molecular Weight339.53

storage temp2-8°C

Hazard Xn: Harmful;
Risk 22
Safety

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion: dyspnea, cardiac and pulmonary changes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide (CAS NO.3737-09-5):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38 
22:  Harmful if swallowed
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 36-26
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	46154ug/kg (46.154mg/kg)	BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Medical Journal of Australia. Vol. 2, Pg. 335, 1978.
dog	LDLo	intravenous	36mg/kg (36mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: REGIDITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 114, 1962.
guinea pig	LDLo	intravenous	24900ug/kg (24.9mg/kg)		Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
human	TDLo	oral	4286ug/kg (4.286mg/kg)	CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	New England Journal of Medicine. Vol. 302, Pg. 614, 1980.
man	LDLo	oral	11429ug/kg (11.429mg/kg)		Journal of Forensic Sciences. Vol. 32, Pg. 1813, 1987.
mouse	LD50	intraperitoneal	114mg/kg (114mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1628, 1971.
mouse	LD50	intravenous	26mg/kg (26mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: REGIDITY	United States Patent Document. Vol. #4237139,
mouse	LD50	oral	352mg/kg (352mg/kg)		Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse	LD50	subcutaneous	305mg/kg (305mg/kg)		Drugs in Japan Vol. 6, Pg. 319, 1982.
rabbit	LDLo	intravenous	42200ug/kg (42.2mg/kg)		Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat	LD50	intraperitoneal	170mg/kg (170mg/kg)		Drugs in Japan Vol. 6, Pg. 319, 1982.
rat	LD50	intravenous	39100ug/kg (39.1mg/kg)		Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat	LD50	oral	333mg/kg (333mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
rat	LD50	subcutaneous	800mg/kg (800mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 829, 1978.
women	TDLo	oral	84mg/kg/3W-I (84mg/kg)	SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE BEHAVIORAL: HEADACHE LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI	Mayo Clinic Proceedings. Vol. 65, Pg. 1030, 1990.
women	TDLo	unreported	700mg/kg/13W- (700mg/kg)	BEHAVIORAL: COMA ENDOCRINE: HYPOGLYCEMIA	Annales de Medecine Interne. Vol. 146, Pg. 209, 1995.