37686-84-3|Urea,N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]-Products Supply

Urea,N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- cas no:37686-84-3

Synonyms: Ergoline,urea deriv.; Indolo[4,3-fg]quinoline, urea deriv.; (+)-(5R,8S,10R)-Terguride;(+)-Terguride; (5R,8S,10R)-Terguride; 6-Methyl-8a-(diethylcarbamoylamino)ergoline; 9,10a-Dihydrolisuride;N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea; TDHL; Tergurid; Terguride; trans-Dihydrolisuride

Identification

NameUrea,N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]-
CAS37686-84-3
SynonymsErgoline,urea deriv.; Indolo[4,3-fg]quinoline, urea deriv.; (+)-(5R,8S,10R)-Terguride;(+)-Terguride; (5R,8S,10R)-Terguride; 6-Methyl-8a-(diethylcarbamoylamino)ergoline; 9,10a-Dihydrolisuride;N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea; TDHL; Tergurid; Terguride; trans-Dihydrolisuride
EINECS(EC#)253-624-2
Molecular FormulaC20H28 N4 O
Molecular Weight340.52

Chemical Properties

refractive index1.639

Safety Data

Hazard T
Safety

Poison by ingestion and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Hazard Codes: T
Risk Statements:
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
Safety Statements:
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	oral	> 500mg/kg (500mg/kg)		Drugs in Japan Vol. -, Pg. 832, 1995.
mouse	LD50	intraperitoneal	272mg/kg (272mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: INCONTINENCE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
mouse	LD50	intravenous	75mg/kg (75mg/kg)		Collection of Czechoslovak Chemical Communications. Vol. 52, Pg. 2983, 1987.
mouse	LD50	oral	160mg/kg (160mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: INCONTINENCE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
mouse	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat	LD50	intraperitoneal	2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: INCONTINENCE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat	LD50	oral	100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: INCONTINENCE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.

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Urea,N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- cas no:37686-84-3

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