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Home > products > 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-

1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)- cas no:38194-50-2

Synonyms: 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-;(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Aflodac;Arthrocine;Artribid;Clinoril;Clisundac;Imbaral;MK 231;Mobilin;Reumofil;Reumyl;Sudac;

Identification
Name1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-
CAS38194-50-2
Synonyms1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-;(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Aflodac;Arthrocine;Artribid;Clinoril;Clisundac;Imbaral;MK 231;Mobilin;Reumofil;Reumyl;Sudac;
EINECS(EC#)253-819-2
Molecular FormulaC20H17FO3S
Molecular Weight356.41
Chemical Properties
AppearanceYellow solid.
refractive index1.672
storage tempKeep tightly closed.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful;
Risk R22
Safety

Hazard Codes of Sulindac (CAS NO.38194-50-2): HarmfulXn
Risk Statements: 22-63-42/43 
R22: Harmful if swallowed. 
R63: Possible risk of harm to the unborn child. 
R42/43: May cause sensitization by inhalation and skin contact.
RIDADR: 3249
RTECS: NK8226000
HazardClass: 6.1(b)
PackingGroup: III
Human poison by ingestion. Experimental poison by ingestion, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. Human systemic effects by ingestion: anorexia, respiratory effects, salivary gland effects, nausea or vomiting, impaired liver function, luekopenia, fever, and metabolic acidosis. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of F and SOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant LDLo oral 12mg/kg/2D-I (12mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BLOOD: HEMORRHAGE
Acta Paediatrica. Vol. 85, Pg. 884, 1996.
man TDLo oral 34mg/kg/6D-I (34mg/kg)   Journal of Rheumatology. Vol. 13, Pg. 1084, 1986.
man TDLo oral 43mg/kg/10D-I (43mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: LEUKOPENIA
JAMA, Journal of the American Medical Association. Vol. 244, Pg. 269, 1980.
man TDLo oral 343mg/kg (343mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995.
mouse LD50 intraperitoneal 305mg/kg (305mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
mouse LD50 oral 507mg/kg (507mg/kg)   Drugs in Japan Vol. 6, Pg. APP-6, 1982.
mouse LD50 subcutaneous 398mg/kg (398mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat LD50 intraperitoneal 289mg/kg (289mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat LD50 oral 264mg/kg (264mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rat LD50 subcutaneous 336mg/kg (336mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
women LDLo oral 112mg/kg/2W-I (112mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Journal of Rheumatology. Vol. 10, Pg. 512, 1983.
women TDLo oral 8mg/kg/10H-I (8mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Clinical Gastroenterology. Vol. 8, Pg. 569, 1986.

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