38194-50-2|1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-Products Supply

1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)- cas no:38194-50-2

Synonyms: 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-;(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Aflodac;Arthrocine;Artribid;Clinoril;Clisundac;Imbaral;MK 231;Mobilin;Reumofil;Reumyl;Sudac;

Identification

Name1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-
CAS38194-50-2
Synonyms1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (Z)-;(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Aflodac;Arthrocine;Artribid;Clinoril;Clisundac;Imbaral;MK 231;Mobilin;Reumofil;Reumyl;Sudac;
EINECS(EC#)253-819-2
Molecular FormulaC₂₀H₁₇FO₃S
Molecular Weight356.41

Chemical Properties

AppearanceYellow solid.
refractive index1.672
storage tempKeep tightly closed.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful;
Risk R22
Safety

Hazard Codes of Sulindac (CAS NO.38194-50-2): Harmful Xn
Risk Statements: 22-63-42/43
R22: Harmful if swallowed.
R63: Possible risk of harm to the unborn child.
R42/43: May cause sensitization by inhalation and skin contact.
RIDADR: 3249
RTECS: NK8226000
HazardClass: 6.1(b)
PackingGroup: III
Human poison by ingestion. Experimental poison by ingestion, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. Human systemic effects by ingestion: anorexia, respiratory effects, salivary gland effects, nausea or vomiting, impaired liver function, luekopenia, fever, and metabolic acidosis. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of F⁻ and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
infant	LDLo	oral	12mg/kg/2D-I (12mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BLOOD: HEMORRHAGE	Acta Paediatrica. Vol. 85, Pg. 884, 1996.
man	TDLo	oral	34mg/kg/6D-I (34mg/kg)		Journal of Rheumatology. Vol. 13, Pg. 1084, 1986.
man	TDLo	oral	43mg/kg/10D-I (43mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: LEUKOPENIA	JAMA, Journal of the American Medical Association. Vol. 244, Pg. 269, 1980.
man	TDLo	oral	343mg/kg (343mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995.
mouse	LD50	intraperitoneal	305mg/kg (305mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
mouse	LD50	oral	507mg/kg (507mg/kg)		Drugs in Japan Vol. 6, Pg. APP-6, 1982.
mouse	LD50	subcutaneous	398mg/kg (398mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat	LD50	intraperitoneal	289mg/kg (289mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat	LD50	oral	264mg/kg (264mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rat	LD50	subcutaneous	336mg/kg (336mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
women	LDLo	oral	112mg/kg/2W-I (112mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Journal of Rheumatology. Vol. 10, Pg. 512, 1983.
women	TDLo	oral	8mg/kg/10H-I (8mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of Clinical Gastroenterology. Vol. 8, Pg. 569, 1986.

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