Minoxidil cas no:38304-91-5
Synonyms: Mimosine;Minoxidil(USP 24);Minoxidil USP/BP;Loniten (TN);U-10,858;2,4-Diamino-6-piperidinopyrimidine 3-N-oxide;Prexidil;6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine;Alopexil;U 10858;Regaine;Minossidile [Italian];Prestwick_521;Minoximen;2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide;Loniten;2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine;Minoxidilum [INN-Latin];Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide;Minoxidil (USP);PDP;Tricoxidil;6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide;2,6-Diamino-4-piperidinopyrimidin-1-oxid;Rogaine;Alostil;3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine;6-Piperidino-2,4-diaminopyrimidine 3-oxide;2,4-Pyrimidinediamine,6-(1-piperidinyl)-,3- oxide;2,4-Diamino-6-piperidinopyrimidine 3-oxide;2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian];Theroxidil;4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-;
NameMinoxidil
CAS38304-91-5
SynonymsMimosine;Minoxidil(USP 24);Minoxidil USP/BP;Loniten (TN);U-10,858;2,4-Diamino-6-piperidinopyrimidine 3-N-oxide;Prexidil;6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine;Alopexil;U 10858;Regaine;Minossidile [Italian];Prestwick_521;Minoximen;2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide;Loniten;2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine;Minoxidilum [INN-Latin];Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide;Minoxidil (USP);PDP;Tricoxidil;6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide;2,6-Diamino-4-piperidinopyrimidin-1-oxid;Rogaine;Alostil;3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine;6-Piperidino-2,4-diaminopyrimidine 3-oxide;2,4-Pyrimidinediamine,6-(1-piperidinyl)-,3- oxide;2,4-Diamino-6-piperidinopyrimidine 3-oxide;2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian];Theroxidil;4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-;
EINECS(EC#)253-874-2
Molecular FormulaC9H15N5O
Molecular Weight209.25
AppearanceWhite crystalline powder
refractive index1.724
storage tempKeep in a cool, dry location. Keep containers closed when not in use. Protect from light.
Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety
Hazard Codes:?
Xn,
T+
Risk Statements: 22-36/37/38-26/27/28?
R22:Harmful if swallowed.?
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-45-36/37/39-22?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
LDLo |
oral |
69mg/kg/34W-I (69mg/kg) |
CARDIAC: PERICARDITIS
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
Western Journal of Medicine. Vol. 143, Pg. 527, 1985. |
| man |
TDLo |
oral |
107ug/kg/3D-I (0.107mg/kg) |
BLOOD: THROMBOCYTOPENIA |
Annals of Internal Medicine. Vol. 92, Pg. 874, 1980. |
| mouse |
LD50 |
intraperitoneal |
560mg/kg (560mg/kg) |
? |
Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982. |
| mouse |
LD50 |
intravenous |
51mg/kg (51mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977. |
| mouse |
LD50 |
oral |
> 1gm/kg (1000mg/kg) |
? |
Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982. |
| rat |
LD50 |
intraperitoneal |
759mg/kg (759mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977. |
| rat |
LD50 |
intravenous |
49mg/kg (49mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977. |
| rat |
LD50 |
oral |
1321mg/kg (1321mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977. |
| women |
TDLo |
oral |
200ug/kg (0.2mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
GASTROINTESTINAL: NAUSEA OR VOMITING |
Archives of Internal Medicine. Vol. 146, Pg. 2075, 1986.
? |
