2-Propanol,1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)- cas no:38363-40-5

Name2-Propanol,1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)-
CAS38363-40-5
Synonyms2-Propanol,1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (S)-; (-)-(S)-Penbutolol;(-)-Isopenbutolol; (-)-Penbutolol; (S)-Penbutolol; Betapressin; HOE 893; HOE893D; Levopenbutolol; Penbutolol; l-Penbutolol
EINECS(EC#)253-074-3
Molecular FormulaC18H29 N O2
Molecular Weight291.48

refractive index1.527

Safety

Poison by ingestion and intravenous routes. Mutation data reported. When Penbutolol (CAS NO.38363-40-5) is heated to decomposition, it emits toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 20mg/kg (20mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
mouse	LD50	intravenous	18mg/kg (18mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
mouse	LD50	oral	1230mg/kg (1230mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rabbit	LD50	intravenous	17mg/kg (17mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rabbit	LD50	oral	300mg/kg (300mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rat	LD50	intravenous	22mg/kg (22mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rat	LD50	oral	1265mg/kg (1265mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.