Erythromycin lactobionate cas no:3847-29-8

NameErythromycin lactobionate
CAS3847-29-8
SynonymsErythromycin lactobionate [JAN];1334-29-8;Erythromycin lactobionate (1:1) (salt);Lactobionic acid, compd. with erythromycin (1:1);Erythromycin. compd. with lactobionic acid;Erythrocin (TN);D-Gluconic acid, 4-O-beta-D-galactopyranosyl-, compd. with erythromycin (1:1) (9CI);Erythromycin, 4-O-beta-D-galactopyranosyl-D-gluconate (salt);Erythromycin mono(4-O-beta-D-galactopyranosyl-D-gluconate) (salt);(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione; (2R,3S,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanoic acid;4-O-beta-D-Galactopyranosyl-D-gluconic acid compd. with erythromycin;Erythomycin lactobionate;
EINECS(EC#)223-348-7
Molecular FormulaC₄₉H₈₉NO₂₅
Molecular Weight0

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OD7320000

CAS REGISTRY NUMBER :

3847-29-8

LAST UPDATED :

199712

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C37-H67-N-O13.C12-H22-O12

MOLECULAR WEIGHT :

1092.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

61 mg/kg/1D-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Ear) - tinnitus Sense Organs and Special Senses (Ear) - changes in vestibular functions

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

60 mg/kg/1D-I

TOXIC EFFECTS :

Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate increase, without fall in BP

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

240 mg/kg/4D-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Ear) - change in acuity

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

735 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

50 gm/kg/6W-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

Gene conversion and mitotic recombination

TEST SYSTEM :

Yeast - Saccharomyces cerevisiae

DOSE/DURATION :

1 gm/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,357,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3884 No. of Facilities: 98 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 3317 (estimated) No. of Female Employees: 1523 (estimated)