Tityustoxin cas no:39465-37-7

NameTityustoxin
CAS39465-37-7
SynonymsTsTX
Molecular Weight0

Appearancelyophilized powder
storage temp−20°C

Safety

A poison by intraperitoneal route. Moderately toxic by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.Safety information of Tityustoxin (CAS NO.39465-37-7):
WGK Germany:  3
RTECS:  XR3030000

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	160ug/kg (0.16mg/kg)		Toxicology Letters. Vol. 71, Pg. 97, 1994.
rat	LDLo	intravenous	1mg/kg (1mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Agents and Actions, A Swiss Journal of Pharmacology. Vol. 8, Pg. 113, 1978.

The venom of Tityus serrulatus is the most potent of the toxins from the species (Clemente, Rossoni et al. 1999). Tityustoxin-1, TsTX-I is the most toxic protein among the neurotoxins in this venom, with an intravenous and intracisternal LD50 (mouse) of 76 k 9 and 1.1 + 0.3 /lg/kg, respectively. The identification of TsTX-I as a potent component of T. serrulatus venom characterized it as the major and main neurotoxin from this venom (Correa, Sampaio et al. 1997). Poisoning effects in man evoked by T. serrulatus venom are sialorrhea, lacrimation and rhinorrhea. (Clemente, Rossoni et al. 1999) and acute pancreatitis (Correa, Sampaio et al. 1997). Catecholamines by the adrenal glands and postganglionic nerve terminals and Ach by ganglions and postganglionic nerve terminals are released when the poison strikes. Also other neurotransmitters are released by the whole venom and isolated toxins (Correa, Sampaio et al. 1997). In rats, the Tityustoxin caused dramatic effects on the circulatory and respiratory systems, consisting of hypotension, tachypnea, hyperpnea, ataxic and gasping breathing. Following these initial effects, 5 or 10 pg of TsTX induced hypertension and hyperpnea. The largest dose produced apnea and death about 70 min later (Lima and Freire-Maia 1977).