Methacycline hydrochloride cas no:3963-95-9
Synonyms: 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, (4S,4aR,5S,5aR,12aS)- (9CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,12aa)]-;6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline hydrochloride;6-Demethyl-6-deoxy-6-methylene-5-hydroxytetracycline hydrochloride;6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride;6-Methylene-5-hydroxytetracycline chlorohydrate;6-Methylene-5-hydroxytetracycline hydrochloride;6-Methyleneoxytetracyclinehydrochloride;Adriamicina;Ciclobiotic;Germiciclin;Londomycin;Metacyclinhydrochloride;Metadomus;Methacyclinehydrochloride;Methacycline monohydrochloride;Metilenbiotic;Optimycin;Physiomycine;Rindex;
NameMethacycline hydrochloride
CAS3963-95-9
Synonyms2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, (4S,4aR,5S,5aR,12aS)- (9CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,12aa)]-;6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline hydrochloride;6-Demethyl-6-deoxy-6-methylene-5-hydroxytetracycline hydrochloride;6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride;6-Methylene-5-hydroxytetracycline chlorohydrate;6-Methylene-5-hydroxytetracycline hydrochloride;6-Methyleneoxytetracyclinehydrochloride;Adriamicina;Ciclobiotic;Germiciclin;Londomycin;Metacyclinhydrochloride;Metadomus;Methacyclinehydrochloride;Methacycline monohydrochloride;Metilenbiotic;Optimycin;Physiomycine;Rindex;
EINECS(EC#)223-568-3
Molecular FormulaC22H23ClN2O8
Molecular Weight478.8796
AppearanceSolid
Safety
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. An antibacterial agent. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Safety Statements: 24/25-22
S24/25: Avoid contact with skin and eyes.
S22: Do not breathe dust.
RTECS: QI9276000
Attention:
1. Storage: Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
288mg/kg (288mg/kg) |
|
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
| mouse |
LD50 |
intravenous |
193mg/kg (193mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 818, 1982. |
| mouse |
LD50 |
oral |
3450mg/kg (3450mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 818, 1982. |
| rat |
LD50 |
intraperitoneal |
252mg/kg (252mg/kg) |
|
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
| rat |
LD50 |
intravenous |
202mg/kg (202mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 818, 1982. |
| rat |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 818, 1982. |
