404-82-0|Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (1:1)Products Supply

Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (1:1) cas no:404-82-0

Synonyms: Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (9CI); Phenethylamine, N-ethyl-a-methyl-m-(trifluoromethyl)-, hydrochloride (7CI,8CI);(?à)-Fenfluramine chloride; (?à)-Fenfluramine hydrochloride;1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride; Fenfluraminehydrochloride; Ganal; HHR-965; N-Ethyl-a-methyl-m-(trifluoromethyl)phenethylaminehydrochloride; Ponderal; Ponderax; Ponderex; Pondimin; Pondmin; Racemicfenfluramine hydrochloride; S 768; dl-Fenfluramine hydrochloride

Identification

NameBenzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (1:1)
CAS404-82-0
SynonymsBenzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (9CI); Phenethylamine, N-ethyl-a-methyl-m-(trifluoromethyl)-, hydrochloride (7CI,8CI);(?à)-Fenfluramine chloride; (?à)-Fenfluramine hydrochloride;1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride; Fenfluraminehydrochloride; Ganal; HHR-965; N-Ethyl-a-methyl-m-(trifluoromethyl)phenethylaminehydrochloride; Ponderal; Ponderax; Ponderex; Pondimin; Pondmin; Racemicfenfluramine hydrochloride; S 768; dl-Fenfluramine hydrochloride
EINECS(EC#)206-968-2
Molecular FormulaC12H16 F3 N . Cl H
Molecular Weight267.72

Chemical Properties

storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T: Toxic;
Risk R25
Safety

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F⁻, NO_x, and HCl.
Hazard Codes of Fenfluramine hydrochloride (CAS NO.404-82-0): Toxic T
Risk Statements: 25
R25: Toxic if swallowed.
Safety Statements: 7-16-36/37-45
S7: Keep container tightly closed.
S16: Keep away from sources of ignition.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DA0295500
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	oral	60mg/kg (60mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
child	LDLo	oral	70mg/kg (70mg/kg)	CARDIAC: OTHER CHANGES	Clinical Toxicology. Vol. 14, Pg. 97, 1979.
dog	LD50	intravenous	23mg/kg (23mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING BEHAVIORAL: EXCITEMENT	Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
dog	LD50	oral	100mg/kg (100mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
guinea pig	LD50	intraperitoneal	100mg/kg (100mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
human	TDLo	oral	7mg/kg (7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 1, Pg. 740, 1967.
mouse	LD50	intraperitoneal	92mg/kg (92mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1561, 1978.
mouse	LD50	intravenous	90mg/kg (90mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
mouse	LD50	oral	170mg/kg (170mg/kg)		Therapie. Vol. 20, Pg. 297, 1965.
rabbit	LD50	oral	50mg/kg (50mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat	LD50	intraperitoneal	90mg/kg (90mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat	LD50	oral	69mg/kg (69mg/kg)	BEHAVIORAL: FLUID INTAKE	Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
women	TDLo	oral	36mg/kg (36mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: SLEEP BEHAVIORAL: TREMOR	Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 161, 1995.

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Snow drugs lab Co., Ltd: Tel:86-22-58951207; Address: BaoHang No.1 Binhai New Area

Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (1:1) cas no:404-82-0

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