Alfacalcidol cas no:41294-56-8
Synonyms: 9,10-Secocholesta-5,7,10(19)-triene-1,3-diol,(1a,3b,5Z,7E)- (9CI);(1S)-Hydroxycalciol;1-Hydroxyvitamin D3;1a-Hydroxycholecalciferol;1a-Hydroxyvitamin D3;Alfarol;Alpha D3;Alfacalcidolum;Alpharol;Bondiol;EinsAlpha;Etalpha;Oxydevit;Un Alfa;Un Alpha;a-Calcidol;
NameAlfacalcidol
CAS41294-56-8
Synonyms9,10-Secocholesta-5,7,10(19)-triene-1,3-diol,(1a,3b,5Z,7E)- (9CI);(1S)-Hydroxycalciol;1-Hydroxyvitamin D3;1a-Hydroxycholecalciferol;1a-Hydroxyvitamin D3;Alfarol;Alpha D3;Alfacalcidolum;Alpharol;Bondiol;EinsAlpha;Etalpha;Oxydevit;Un Alfa;Un Alpha;a-Calcidol;
EINECS(EC#)255-297-1
Molecular FormulaC27H44O2
Molecular Weight400.63706
Appearancewhite to off-white crystalline powder
refractive index1.534
storage temp?20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T+: Very toxic;Xi: Irritant;
Risk R26/27/28
Safety
Hazard Codes Alfacalcidolum (CAS NO.41294-56-8):?
T+,
Xi
Risk Statements: 26/27/28-36/37/38?
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37-45-26?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: VS2851000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: I
HS Code 29361000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
200ug/kg (0.2mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978. |
| dog |
LD50 |
oral |
500ug/kg (0.5mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978. |
| mouse |
LD50 |
intravenous |
56ug/kg (0.056mg/kg) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
MUSCULOSKELETAL: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Toxicology and Applied Pharmacology. Vol. 36, Pg. 323, 1976. |
| mouse |
LD50 |
oral |
440ug/kg (0.44mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BLOOD: CHANGES IN SPLEEN
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977. |
| mouse |
LD50 |
subcutaneous |
55ug/kg (0.055mg/kg) |
? |
PCT Vol. #86-05395, |
| rat |
LD50 |
intravenous |
101ug/kg (0.101mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
BLOOD: CHANGES IN SPLEEN |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 653, 1978. |
| rat |
LD50 |
oral |
340ug/kg (0.34mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
ENDOCRINE: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977. |
| rat |
LD50 |
subcutaneous |
40ug/kg (0.04mg/kg) |
? |
PCT Vol. #86-05395, |
