1,1-Cyclobutanedicarboxylatodiammineplatinum (II) cas no:41575-94-4
Synonyms: diammine(1,1-cyclobutanedicarboxylato)-platinum(I; Carboplatin; 1,1-Cyclobutanedicarboxylate diamine platinum(II); Paraplatin; CBDCA; cis-(1,1-Cyclobutanedicarboxylato)diamineplatinum(II); cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum, diamine(1,1-cyclobutanedicarboxylato(2-)-O,O')-,(SP-4-2)-; 1,1-Cyclobutanedicarboxylatodiammineplatinum
Name1,1-Cyclobutanedicarboxylatodiammineplatinum (II)
CAS41575-94-4
Synonymsdiammine(1,1-cyclobutanedicarboxylato)-platinum(I; Carboplatin; 1,1-Cyclobutanedicarboxylate diamine platinum(II); Paraplatin; CBDCA; cis-(1,1-Cyclobutanedicarboxylato)diamineplatinum(II); cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum, diamine(1,1-cyclobutanedicarboxylato(2-)-O,O')-,(SP-4-2)-; 1,1-Cyclobutanedicarboxylatodiammineplatinum
EINECS(EC#)255-446-0
Molecular FormulaC6H12N2O4Pt
Molecular Weight373.26436
Appearancewhite crystalline powder
storage tempStore at RT
Hazard T:Toxic
Risk R46;R61;R20/21;R42/43
Safety
Hazard Codes of?Carboplatin (CAS NO.41575-94-4):?
T
Risk Statements: 46-61-20/21/22-42/43?
R46: May cause heritable genetic damage.?
R61: May cause harm to the unborn child.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 53-22-26-36/37/39-45?
S53: Avoid exposure - obtain special instructions before use.?
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
WGK Germany: 3
?
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
> 31200ug/kg (31.2mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 288, 1990. |
| mammal (species unspecified) |
LD50 |
unreported |
158mg/kg (158mg/kg) |
? |
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 22, Pg. 56, 1987.
Link to PubMed |
| mouse |
LD50 |
intraperitoneal |
118mg/kg (118mg/kg) |
? |
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 27, Pg. 611, 1992. |
| mouse |
LD50 |
intravenous |
89360ug/kg (89.36mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
unreported |
180mg/kg (180mg/kg) |
? |
Recent Results in Cancer Research. Vol. 48, Pg. 12, 1974. |
| rat |
LD50 |
intravenous |
60900ug/kg (60.9mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
National Technical Information Service. Vol. PB288-374, |
| rat |
LD50 |
oral |
343mg/kg (343mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 288, 1990. |
| rat |
LD50 |
subcutaneous |
72mg/kg (72mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 288, 1990. |
